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Impacto funcional de la inhibición farmacológica de Tmem176b en diferentes subpoblaciones de células dendríticas
(Udelar. FM, 2021)
Nuestro grupo ha reportado que la proteína Tmem176b es un canal/transportador iónico intracelular fuertemente expresado en células dendríticas (DCs), que bloquea la respuesta inmune anti-tumoral. Identificamos al compuesto ...
TMEM176A and TMEM176B are candidate regulators of inhibition of dendritic cell maturation and function after chronic spinal cord injury
(Mary Ann Liebert, 2020-02)
Inhibition of dendritic cell maturation and activation, together with abnormal functioning of cell-mediated immunity, has been reported in chronic spinal cord injury (SCI). The development of immune-based therapies could: ...
Targeting TMEM176B enhances antitumor immunity and augments the efficacy of immune checkpoint blockers by unleashing inflammasome activation
(Cell Press, 2019-05)
Although immune checkpoint blockers have yielded significant clinical benefits in patients with different malignancies, the efficacy of these therapies is still limited. Here, we show that disruption of transmembrane protein ...
Autologous dendritic cells prolong allograft survival through tmem176b-dependent antigen cross-presentation
(Wiley Blackwell Publishing, Inc, 2014-04-14)
The administration of autologous (recipient-derived) tolerogenic dendritic cells (ATDCs) is under clinical evaluation. However, the molecular mechanisms by which these cells prolong graft survival in a donor-specific manner ...
Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers
(Wiley Blackwell Publishing, Inc, 2020-03)
Immune checkpoint blockers improve the overall survival of a limitednumber of patients among different cancers. Identifying pathways thatinfluence the immunological and clinical response to treatment is criticalto improve ...
Estudio de mecanismos efectores y contra-reguladores mediados por la sobre-activación de inflamasoma durante la respuesta anti-tumoral
(Udelar. FM, 2021)
La manipulación del sistema inmune utilizando inmunoterapias para desencadenar respuestas anti-tumorales ha revolucionado el tratamiento de una variedad de cánceres, sin embargo, pocos pacientes se benefician de las terapias ...
Prospecting genes associated with navel length, coat and scrotal circumference traits in Canchim cattle
(2018-04-01)
The aim of this work was to identify genomic regions and genes in association with the navel length, coat and scrotal circumference traits of Canchim breed of cattle, using genome-wide association studies (GWAS). Imputed ...
Estudio de mecanismos moleculares asociados a la proliferación y sobrevida del clon tumoral en la Leucemia Linfoide Crónica : hacia la identificación de un posible blanco terapéutico
(Udelar. FM, 2020)
La Leucemia Linfoide Crónica (LLC) es una neoplasia caracterizada por la acumulación de Linfocitos B (LB) maduros en sangre periférica, médula ósea y órganos linfoides secundarios (OLS). Es la leucemia más frecuente en ...
Objetos Virtuales de Aprendizaje y su contribución a las competencias matemáticas de los estudiantes de tercer grado
(Universidad de la CostaMaestría en Educación - Modalidad Virtual, 2019)
Identification of transcriptomic responses related to normal, healthy and accelerated aging
(Universidad del RosarioDoctorado en Ciencias BiomédicasFacultad de Ciencias Naturales y Matemáticas, 2018)
Aging is defined as the reduction in the physiological and adaptive capabilities of organisms with the passage of time. The accumulation of DNA damage could be the central event on which other factors related to the aging ...