Buscar
Mostrando ítems 1-10 de 1278
Presence of structural homologs of ubiquitin in haloalkaliphilic Archaea
(Springer, 2009-09)
Ubiquitin, a protein widely conserved in eukaryotes, is involved in many cellular processes, including proteolysis. While sequences encoding ubiquitin-like proteins have not been identified in prokaryotic genomes sequenced ...
The β-isoform of heat shock protein hsp-90 is structurally related with human microtubule-interacting protein Mip-90
(1999)
Through major research advances in the study of cytoskeletal organization, an integrated view of the complexity of this system has emerged. Recent findings on the microtubule-interacting protein Mip-90, which associates ...
Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models
(Royal Society of Chemistry, 2015-07)
With >800 members in humans, the G protein-coupled receptor (GPCR) super-family is the target for more than 30% of the marketed drugs. The recent boom in GPCR crystallography has enabled the solution of ∼30 different GPCR ...
Homology modeling in a dynamical world
(John Wiley & Sons Inc, 2017-11)
A key concept in template‐based modeling (TBM) is the high correlation between sequence and structural divergence, with the practical consequence that homologous proteins that are similar at the sequence level will also ...
Computational analysis and functional prediction of ubiquitin hypothetical protein: A possible target in parkinson disease
(Bentham Science Publishers, 2016)
DBMODELING - A database applied to the study of protein targets from genome projects
(Humana Press Inc, 2006-01-01)
Genome sequencing efforts are providing us with complete genetic blueprints for hundreds of organisms. We are now faced with assigning, understanding, and modifying the functions of proteins encoded by these genomes. ...
DBMODELING - A database applied to the study of protein targets from genome projects
(Humana Press Inc, 2006-01-01)
Genome sequencing efforts are providing us with complete genetic blueprints for hundreds of organisms. We are now faced with assigning, understanding, and modifying the functions of proteins encoded by these genomes. ...
Gene Families, Epistasis and the Amino Acid Preferences of Protein Homologs
(SAGE PUBLICATIONS LTD, 2019)
In order to preserve structure and function, proteins tend to preferentially conserve amino acids at particular sites along the sequence. Because mutations can affect structure and function, the question arises whether the ...