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The corticotropin-releasing hormone network and the hypothalamic-pituitary- adrenal axis: Molecular and cellular mechanisms involved
(Karger, 2011-07)
Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also widely distributed in extrahypothalamic circuits, where it acts as ...
Endocrinology and the brain: Corticotropin-Releasing Hormone signaling
(BioScientifica, 2017-07-14)
Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to ...
Deletion of CRH From GABAergic Forebrain Neurons Promotes Stress Resilience and Dampens Stress-Induced Changes in Neuronal Activity
(Frontiers Media Sa, 2019-09-20)
Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-related psychopathologies such as depression and anxiety. Although most studies have linked CRH/CRH receptor 1 signaling to ...
Fetal undernutrition induces overexpression of CRH mRNA and CRH protein in hypothalamus and increases CRH and corticosterone in plasma during postnatal life in the rat
(ELSEVIER IRELAND LTD, 2008-12-19)
Prenatal undernutrition induces a variety of cardiovascular alterations inmammalswhenadults, including
hypertension and hypercortisolism, which are thought to be caused by decreased glucocorticoid feedback
control of the ...
Different cAMP sources are critically involved in G protein-coupled receptor CRHR1 signaling
(Rockefeller University Press, 2016-07)
Corticotropin-releasing hormone receptor 1 (CRHR1) activates G protein-dependent and internalization-dependent signaling mechanisms. Here, we report that the cyclic AMP (cAMP) response of CRHR1 in physiologically relevant ...
Mecanismos moleculares involucrados en la señalización celular de la hormona CRH en el sistema nervioso centralMolecular mechanisms involved in CRH signaling in the central nervous system
(Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, 2013)
B-Raf and CRHR1 internalization mediate biphasic ERK1/2 activation by CRH in hippocampal HT22 Cells.
(Endocrine Soc, 2013-03)
CRH is a key regulator of neuroendocrine, autonomic, and behavioral response to stress. CRH-stimulated CRH receptor 1 (CRHR1) activates ERK1/2 depending on intracellular context. In a previous work, we demonstrated that ...
New insights into melatonin signaling in hamster Leydig cells
(Academic Press Inc Elsevier Science, 2012-08)
We have previously described that melatonin inhibits androgen production in hamster testes via melatonin subtype 1a (mel1a) receptors and the local corticotrophin-releasing hormone (CRH) system. This study attempted to ...
CAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells
(Nature Publishing Group, 2017-12)
Corticotropin-releasing hormone receptor 1 (CRHR1) activates the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs). Both cAMP sources were shown to be required for the phosphorylation ...
Avances en la terapéutica molecular de la depresión
(Venezuela, 2015)