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Calreticulin and Arginylated Calreticulin Have Different Susceptibilities to Proteasomal Degradation
(American Society For Biochemistry And Molecular Biology, 2015-06)
Post-translational arginylation has been suggested to target proteins for proteasomal degradation. The degradation mechanism for arginylated calreticulin (R-CRT) localized in the cytoplasm is unknown. To evaluate the effect ...
Calreticulin-dimerization induced by post-translational arginylation is critical for stress granules scaffolding
(Elsevier, 2013-04)
Protein arginylation mediated by arginyl-tRNA protein transferase is a post-translational modification that occurs widely in biology, it has been shown to regulate protein and properties and functions. Post-translational ...
Post-translational protein arginylation in the normal nervous system and in neurodegeneration
(Wiley Blackwell Publishing, Inc, 2016-08)
Post-translational arginylation of proteins is an important regulator of many physiological pathways in cells. This modification was originally noted in protein degradation during neurodegenerative processes, with an ...
Ablation of arginyl-tRNA-protein transferase in oligodendrocytes impairs central nervous system myelination
(Wiley-liss, div John Wiley & Sons Inc., 2021-10)
Addition of arginine (Arg) from tRNA can cause major alterations of structure and function of protein substrates. This post-translational modification, termed protein arginylation, is mediated by the enzyme arginyl-tRNA-protein ...
Arginylated Calreticulin Increases Apoptotic Response Induced by Bortezomib in Glioma Cells
(Humana Press, 2019-03)
After retrotranslocation from the endoplasmic reticulum to the cytoplasm, calreticulin is modified by the enzyme arginyltransferase-1 (ATE1). Cellular levels of arginylated calreticulin (R-CRT) are regulated in part by the ...
Evidence of essential arginyl residues in rabbit muscle pyruvate kinase
(1979)
Rabbit muscle pyruvate kinase is inactivated by 2,3-butanedione in borate buffer. The inactivation follows pseudo-first-order kinetics with a calculated second-order rate constant of 4.6 m-1 min-1. The modification can be ...
Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats
(2005-02-01)
Proteinase-activated receptor-2 (PAR2) is a G-protein-coupled receptor that mediates cellular responses to extracellular proteinases. Since PAR2 is expressed by oral epithelial cells, osteoblasts, and gingival fibroblasts, ...
Proteinase-activated receptor-2 (PAR2) agonist causes periodontitis in rats
(2005-02-01)
Proteinase-activated receptor-2 (PAR2) is a G-protein-coupled receptor that mediates cellular responses to extracellular proteinases. Since PAR2 is expressed by oral epithelial cells, osteoblasts, and gingival fibroblasts, ...
Role of post-translational arginylation in glial cells during CNS myelination
(Wiley, 2019)
Post-translational arginylation of proteins is mediated by Arginyltransferase (Ate1), which modifies multiple substrates, such components of actin cytoskeleton, and modulates biological processes during embryogenesis, cell ...