Role of post-translational arginylation in glial cells during CNS myelination

Abstract

Post-translational arginylation of proteins is mediated by Arginyltransferase (Ate1), which modifies multiple substrates, such components of actin cytoskeleton, and modulates biological processes during embryogenesis, cell migration, proliferation and neuronal growth; however, its role in glia cells is poorly understood. Oligodendrocytes (OLs) are responsible of myelin formation in the central nervous system (CNS), essential for the rapid propagation of neuronal action potential as well as for metabolic support of axons...