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Enzymatic kinetic resolution of racemic ibuprofen: past, present and future
(Taylor & Francis, 2015-06-30)
This review is a journey concerning the investigations of the kinetic resolution of racemic ibuprofen for the last 20 years. The relevancy of the pharmacological uses of the S( + ) enantiomer along with its higher cost ...
Isolation of ibuprofen enantiomers and racemic esters through electrodialysis
(Elsevier Science, 2021-01-15)
The electrodialysis of pure rac-ibuprofen and the products of the enzymatic kinetic resolution of the profen were investigated in order to establish the best conditions for the separation of the ibuprofen from the ethyl ...
Analysis of ibuprofen enantiomers in rat plasma by liquid chromatography with tandem mass spectrometry
(Wiley-Blackwell, 2014-04-01)
A sensitive and selective method for the analysis of ibuprofen enantiomers by LC-MS/MS was developed and validated for the purpose of application in pharmacokinetic studies in small experimental animals. Aliquots of 200 L ...
Ibuprofen-maltodextrin interaction: study of enantiomeric recognition and complex characterization
(Scientific Research, 2013-02)
The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their ...
Enantioselective esterification of racemic ibuprofen with ethanol as reactant and solvent catalyzed by immobilized lipase: experimental and molecular modeling aspects
(John Wiley & Sons Ltd, 2009-05-13)
In the last years enantioselective esterification of racemic ibuprofen performed in organic solvent media and catalyzed by lipases has been proposed as an effective way to increase the concentration of unesterified S-ibuprofen ...
Optimization of enantioselective resolution of racemic ibuprofen by native lipase from Aspergillus niger
(Springer HeidelbergHeidelbergAlemanha, 2006)
An in silico analysis of Ibuprofen enantiomers in high concentrations of sodium chloride with SARS-CoV-2 main protease
(Taylor & Francis, 2021-01)
2020 will be remembered worldwide for the outbreak of Coronavirus disease (COVID-19), which quickly spread until it was declared as a global pandemic. The main protease (Mpro) of SARS-CoV-2, a key enzyme in coronavirus, ...