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Estimation of the Minimum Number of Replication Origins Per Chromosome in any Organism
(Bio-protocol, 2020-10-20)
Eukaryote nuclear genomes predominantly replicate through multiple replication origins. The number of replication origins activated per chromosome during the S-phase duration may vary according to many factors, but the ...
Genome cyclization as strategy for flavivirus RNA replication
(Elsevier Science, 2008-09)
Long-range and local RNA-RNA contacts in viral RNA genomes result in tertiary structures that modulate the function of enhancers, promoters, and silencers during translation, RNA replication, and encapsidation. In the case ...
Molecular characterization of IPNV RNA replication intermediates during the viral infective cycle
(2009)
Infectious Pancreatic Necrosis Virus (IPNV) is a bisegmented, double-stranded RNA virus, which belongs to the Birnaviridae family. In the current study, we have analyzed the RNA replication intermediates (RI) purified ...
Structural rearrangements in the mitochondrial genome of Drosophila melanogaster induced by elevated levels of the replicative DNA helicase
(Oxford Univ Press, 2018-04-06)
Pathological conditions impairing functions of mitochondria often lead to compensatory upregulation of the mitochondrial DNA (mtDNA) replisome machinery, and the replicative DNA helicase appears to be a key factor in ...
Functional RNA Elements in the Dengue Virus Genome
(Molecular Diversity Preservation International, 2011-09-15)
Dengue virus (DENV) genome amplification is a process that involves the viral RNA, cellular and viral proteins, and a complex architecture of cellular membranes. The viral RNA is not a passive template during this process; ...
Virus-Host Interactions Involved in Lassa Virus Entry and Genome Replication
(Multidisciplinary Digital Publishing Institute, 2019-01)
Lassa virus (LASV) is the causative agent of Lassa fever, a human hemorrhagic disease associated with high mortality and morbidity rates, particularly prevalent in West Africa. Over the past few years, a significant amount ...
To assemble or not to assemble: The changing rules of pneumovirus transmission
(Elsevier B.V., 2019)
Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication
(American Society For Microbiology, 2015-03)
The dengue virus genome is a dynamic molecule that adopts different conformations in the infected cell. Here, using RNA folding predictions, chemical probing analysis, RNA binding assays, and functional studies, we identified ...