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New lead compounds in the search for pure antiglucocorticoids and the dissociation of antiglucocorticoid effects
(Pergamon-Elsevier Science Ltd, 2009-02)
Antiglucocorticoids that act as antagonists at the glucocorticoid receptor (GR) level may be used to block or modulate the undesirable effects of glucocorticoid excess (from endogenous or exogenous origin). RU486 developed ...
21-Hydroxy-6,19-epoxyprogesterone: A promising therapeutic agent and a molecular tool for deciphering glucocorticoid action
(Bentham Science Publishers, 2016-06)
Glucocorticoids are steroid hormones that exert most of their effects through their binding to the glucocorticoid receptor (GR), a ligand regulated transcription factor. Although glucocorticoids are widely used in the ...
Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases
(Molecular Diversity Preservation International, 2020-03)
Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases is enhanced. In this brief review, we discuss the ...
Tratamento endócrino dos meningiomas: uma revisãoEndocrine treatment of meningiomas: a review
(Academia Brasileira de Neurologia - ABNEURO, 1995)
Os meningiomas são tumores benignos do sitema nervoso central. Apresentam altas taxas de recidiva e muitas vezes são considerados inoperáveis, como quando se localizam em local de difícil acesso cirúrgico ou quando englobam ...
A putative role for hypothalamic glucocorticoid receptors in hypertension induced by prenatal undernutrition in the rat
(2010)
Prenatal undernutrition induces hypertension later in life, possibly by disturbing the hypothalamo-pituitary-adrenal axis through programming decreased expression of hypothalamic glucocorticoid receptors. We examined the ...
Mifepristone for treatment of metabolic syndrome: beyond cushing’s syndrome
(Frontiers Media, 2020)
A growing body of research indicates that cortisol, the glucocorticoid product of the activation of the hypothalamic-pituitary-adrenal axis, plays a role in the pathophysiology of metabolic syndrome. In this regard, chronic ...
Synergistic lethality of mifepristone and LY294002 in ovarian cancer cells
(Libertas Academica, 2013-01)
We have previously shown that the antiprogestin and antiglucocorticoid mifepristone inhibits the growth of ovarian cancer cells. In this work, we hypothesized that cellular stress caused by mifepristone is limited to ...
Dehydroepiandrosterone and metyrapone partially restore the adaptive humoral and cellular immune response in endotoxin immunosuppressed mice
(Sage Publications, 2013-09)
Prior exposure to endotoxins renders the host temporarily refractory to subsequent endotoxin challenge (endotoxin tolerance). Clinically, this state has also been pointed out as the initial cause of the non-specific humoral ...
Ejes neuroendocrinos del estrés, síndrome metabólico y alteraciones psiquiátricas del síndrome de CushingNeuroendocrine Axis of Stress, Metabolic Syndrome and Psychiatric Disorders in Cushing's Sindrome
(Universidad de Antioquia, Facultad de MedicinaMedellín, Colombia, 2021)