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Ammonia detoxification via ureagenesis in rat hepatocytes involves mitochondrial aquaporin-8 channels
(American Association for the Study of Liver Diseases, 2013-05)
Hepatocyte mitochondrial ammonia detoxification via ureagenesis is critical for the prevention of hyperammonemia and hepatic encephalopathy. Aquaporin-8 (AQP8) channels facilitate the membrane transport of ammonia. Because ...
Experimental bio-artificial liver: Importance of the architectural design on ammonia detoxification performance
(Baishideng Publishing Group Co, 2018-10)
AIM To determine the influence of the construction design over the biological component's performance in an experimental bio-artificial liver (BAL) device. METHODS Two BAL models for liver microorgans (LMOs) were constructed. ...
Lipopolysaccharide impairs hepatocyte ureagenesis from ammonia: Involvement of mitochondrial aquaporin-8
(Elsevier, 2014-03)
We recently reported that hepatocyte mitochondrial aquaporin-8 (mtAQP8) channels facilitate the uptake of ammonia and its metabolism into urea. Here we studied the effect of bacterial lipopolysaccharides (LPS) on ammonia-derived ...
Acidosis-induced downregulation of hepatocyte mitochondrial aquaporin-8 and ureagenesis from ammonia
(Canadian Science Publishing, 2015-05)
It has been proposed that during metabolic acidosis, the liver downregulates mitochondrial ammonia detoxification via ureagenesis, a bicarbonate-consuming process. Since we previously demonstrated that hepatocyte mitochondrial ...
Efeito agudo e subcrônico da amônia sobre a tilápia do Nilo Oreochromis niloticus
(Universidade Federal de Minas GeraisUFMG, 2018-02-09)
The presence of nitrogen compounds in closed environments and commercial fish production is frequent. These compounds can be found in the form of NH3, NO2- and NO3-, which can reach high levels especially in water retention ...
Cold Storage of Liver Microorgans in ViaSpan® and BG35 Solutions. Study of Ammonia Metabolism during normothermic reoxygenation
(Mexican Assoc Hepatology, 2014-03)
Introduction: This work focuses on ammonia metabolism of Liver Microorgans (LMOs) after cold preservation in a normothermic reoxygenation system (NRS). We have previously reported the development of a novel preservation ...
In vitro ruminal degradation of ricin and its effect on microbial growth
(Animal Feed Science and Technology, 2018)
Avaliação laboratorial do uso de solução salina hipertônica e isotônica e de furosemida no tratamento da intoxicação por amônia em bovinos
(Universidade Federal de Santa Maria (UFSM), 2014)
Performance of cold-preserved rat liver Microorgans as the biological component of a simplified prototype model of bioartificial liver
(Baishideng Publishing Group, 2016-11)
AIM: To develop a simplified bioartificial liver (BAL) device prototype, suitable to use freshly and preserved liver Microorgans (LMOs) as biological component.
METHODS: The system consists of 140 capillary fibers through ...
Uso de biomarcadores na avaliação da resposta de larvas e juvenis de pacamã Lophiosilurus alexandri expostos à amônia e ao nitrito em diferentes salinidades e temperaturas
(Universidade Federal de Minas GeraisUFMG, 2017-02-21)
The objective of this study was to evaluate the tolerance (LC50-96h) of the larvae of pacamã Lophiosilurus alexandri, with one and seven days of life in different salinities and larvae with twenty days at the temperatures ...