Otro
Genome-Wide Analysis Reveals Selection for Important Traits in Domestic Horse Breeds
Registro en:
PLoS Genetics, v. 9, n. 1, 2013.
1553-7390
1553-7404
10.1371/journal.pgen.1003211
WOS:000314651500054
2-s2.0-84873515697.pdf
2-s2.0-84873515697
Autor
Petersen, Jessica L.
Mickelson, James R.
Rendahl, Aaron K.
Valberg, Stephanie J.
Andersson, Lisa S.
Axelsson, Jeanette
Bailey, Ernie
Bannasch, Danika
Binns, Matthew M.
Borges, Alexandre Secorun
Brama, Pieter
da Câmara Machado, Artur
Capomaccio, Stefano
Cappelli, Katia
Cothran, E. Gus
Distl, Ottmar
Fox-Clipsham, Laura
Graves, Kathryn T.
Guérin, Gérard
Haase, Bianca
Hasegawa, Telhisa
Hemmann, Karin
Hill, Emmeline W.
Leeb, Tosso
Lindgren, Gabriella
Lohi, Hannes
Lopes, Maria Susana
McGivney, Beatrice A.
Mikko, Sofia
Orr, Nicholas
Penedo, M. Cecilia T.
Piercy, Richard J.
Raekallio, Marja
Rieder, Stefan
Røed, Knut H.
Swinburne, June
Tozaki, Teruaki
Vaudin, Mark
Wade, Claire M.
McCue, Molly E.
Resumen
Intense selective pressures applied over short evolutionary time have resulted in homogeneity within, but substantial variation among, horse breeds. Utilizing this population structure, 744 individuals from 33 breeds, and a 54,000 SNP genotyping array, breed-specific targets of selection were identified using an FST-based statistic calculated in 500-kb windows across the genome. A 5.5-Mb region of ECA18, in which the myostatin (MSTN) gene was centered, contained the highest signature of selection in both the Paint and Quarter Horse. Gene sequencing and histological analysis of gluteal muscle biopsies showed a promoter variant and intronic SNP of MSTN were each significantly associated with higher Type 2B and lower Type 1 muscle fiber proportions in the Quarter Horse, demonstrating a functional consequence of selection at this locus. Signatures of selection on ECA23 in all gaited breeds in the sample led to the identification of a shared, 186-kb haplotype including two doublesex related mab transcription factor genes (DMRT2 and 3). The recent identification of a DMRT3 mutation within this haplotype, which appears necessary for the ability to perform alternative gaits, provides further evidence for selection at this locus. Finally, putative loci for the determination of size were identified in the draft breeds and the Miniature horse on ECA11, as well as when signatures of selection surrounding candidate genes at other loci were examined. This work provides further evidence of the importance of MSTN in racing breeds, provides strong evidence for selection upon gait and size, and illustrates the potential for population-based techniques to find genomic regions driving important phenotypes in the modern horse. © 2013 Petersen et al.
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