Otro
Cardiac remodeling induced by smoking: Concepts, relevance, and potential mechanisms
Registration in:
Inflammation and Allergy - Drug Targets, v. 11, n. 6, p. 442-447, 2012.
1871-5281
10.2174/187152812803589958
2-s2.0-84870257839
Author
Minicucci, Marcos Ferreira
Gaiolla, Paula Schmidt Azevedo
Polegato, Bertha Furlan
Paiva, Sergio A.R.
Zornoff, Leonardo Antonio Mamede
Abstract
Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke exposure is recognized as one of these insults. Indeed, tobacco smoke exposure induces the enlargement of the left-sided cardiac chambers, myocardial hypertrophy, and ventricular dysfunction. Potential mechanisms for these alterations include hemodynamic and neurohormonal changes, oxidative stress, inflammation, nitric oxide bioavailability, matrix metalloproteinases and mitogen-activated protein kinase activation. This review will focus on the concepts, relevance, and potential mechanisms of cardiac remodeling induced by tobacco smoke. © 2012 Bentham Science Publishers.
Subjects
Related items
Showing items related by title, author, creator and subject.
-
Cardiac remodeling induced by smoking: Concepts, relevance, and potential mechanisms
Universidade Estadual Paulista (UNESP) (2012-12-04)Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke ... -
β-carotene attenuates the paradoxical effect of tobacco smoke on the mortality of rats after experimental myocardial infarction
Paiva, Sergio Alberto Rupp de; Novo, Rosangela; Matsubara, Beatriz Bojikian; Matsubara, Luiz Shiguero; Gaiolla, Paula Schmidt Azevedo; Minicucci, Marcos Ferreira; Campana, Álvaro O.; Zornoff, Leonardo Antonio Mamede -
β-carotene attenuates the paradoxical effect of tobacco smoke on the mortality of rats after experimental myocardial infarction
Universidade Estadual Paulista (UNESP) (2005-09-01)The objective of this study was to investigate the effects of exposure to tobacco smoke (ETS) in rats that were or were not supplemented with dietary β-carotene (BC), on ventricular remodeling and survival after myocardial ...