Artículos de revistas
Synthesis Of Azo Carbonate Monomers And Biocompatibility Study Of Poly(azo-carbonate-urethane)s
Registro en:
Rsc Advances. Royal Soc Chemistry, v. 6, p. 79987 - 79997, 2016.
2046-2069
WOS:000382539600082
10.1039/c6ra11075d
Autor
Capitao
R. M.; Santo
R. D. E.; Magalhaes
A.; Assis
D.; da Silva
G. V. J.; Scarim
C. B.; Chelucci
R. C.; Andrade
C. R.; Chung
M. C.; Gonzalez
E. R. P.
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The present work describes the synthesis of azo carbonate monomers by a clean carbonylation synthetic route using di-methylcarbonate. The kinetics study showed a conversion of similar to 98% to bis-carbonates after only six minutes of reaction using triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The preparation of azo-carbonates by means of coupling aryldiazonium salts with bis-carbonate was performed. The reactivity of azo-carbonate monomers was tested in the polycondensation reaction with an aminoalcohol using TBD as a catalyst for the formation of non-isocyanate poly(azo-carbonate-urethane)s PCU 1 and PCU 2. The copolymers' structures were confirmed by FT-IR, NMR and MALDI experiments, which allow us to determine the different terminal groups of the polymer chains formed. The molecular weights and the molecular weight distribution of PCU 1 and PCU 2 were determined by size-exclusion chromatography (SEC) experiments and thermal stabilities were also studied by TG analysis. The biocompatible properties of monomers 4 and 6 and polymers PCU 1 and PCU 2 were investigated by liver, kidney and colon histological analyses. 6 83 79987 79997 FAPESP [2013/24487-6] CNPq CAPES Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)