Synthesis Of Azo Carbonate Monomers And Biocompatibility Study Of Poly(azo-carbonate-urethane)s

dc.creatorCapitao
dc.creatorR. M.; Santo
dc.creatorR. D. E.; Magalhaes
dc.creatorA.; Assis
dc.creatorD.; da Silva
dc.creatorG. V. J.; Scarim
dc.creatorC. B.; Chelucci
dc.creatorR. C.; Andrade
dc.creatorC. R.; Chung
dc.creatorM. C.; Gonzalez
dc.creatorE. R. P.
dc.date2016
dc.date2017-11-13T13:44:18Z
dc.date2017-11-13T13:44:18Z
dc.date.accessioned2018-03-29T05:58:56Z
dc.date.available2018-03-29T05:58:56Z
dc.identifierRsc Advances. Royal Soc Chemistry, v. 6, p. 79987 - 79997, 2016.
dc.identifier2046-2069
dc.identifierWOS:000382539600082
dc.identifier10.1039/c6ra11075d
dc.identifierhttp://pubs.rsc.org/en/content/articlehtml/2016/RA/C6RA11075D
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328732
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1365757
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe present work describes the synthesis of azo carbonate monomers by a clean carbonylation synthetic route using di-methylcarbonate. The kinetics study showed a conversion of similar to 98% to bis-carbonates after only six minutes of reaction using triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The preparation of azo-carbonates by means of coupling aryldiazonium salts with bis-carbonate was performed. The reactivity of azo-carbonate monomers was tested in the polycondensation reaction with an aminoalcohol using TBD as a catalyst for the formation of non-isocyanate poly(azo-carbonate-urethane)s PCU 1 and PCU 2. The copolymers' structures were confirmed by FT-IR, NMR and MALDI experiments, which allow us to determine the different terminal groups of the polymer chains formed. The molecular weights and the molecular weight distribution of PCU 1 and PCU 2 were determined by size-exclusion chromatography (SEC) experiments and thermal stabilities were also studied by TG analysis. The biocompatible properties of monomers 4 and 6 and polymers PCU 1 and PCU 2 were investigated by liver, kidney and colon histological analyses.
dc.description6
dc.description83
dc.description79987
dc.description79997
dc.descriptionFAPESP [2013/24487-6]
dc.descriptionCNPq
dc.descriptionCAPES
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageEnglish
dc.publisherRoyal Soc Chemistry
dc.publisherCambridge
dc.relationRSC Advances
dc.rightsaberto
dc.sourceWOS
dc.subjectDimethyl Carbonate
dc.subjectIn-vivo
dc.subjectPolymers
dc.subjectIntermediate
dc.subjectMethylation
dc.subjectPerformance
dc.subjectChemistry
dc.subjectCatalysis
dc.subjectMemory
dc.subjectDbu
dc.titleSynthesis Of Azo Carbonate Monomers And Biocompatibility Study Of Poly(azo-carbonate-urethane)s
dc.typeArtículos de revistas


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