Artículos de revistas
Changes In Mmps And Inflammatory Cells In Experimental Gingivitis.
Registration in:
Histology And Histopathology. v. 24, n. 2, p. 157-66, 2009-Feb.
1699-5848
19085832
Author
Lorencini, Márcio
Silva, Juliete A F
de la Hoz, Cristiane L R
Carvalho, Hernandes F
Stach-Machado, Dagmar R
Institutions
Abstract
In periodontal disease, extensive disorganization of the extracellular matrix promotes the loss of adhesion between the teeth and periodontium. A previous study suggested a reduction in the area occupied by collagen in the gingiva, during the first week of periodontal disease induction, however, the remaining fibers were more compact and thicker. Therefore, it was decided to investigate which of the MMP-2, -9, -14 and RECK, an MMP inhibitor, were involved in these modifications taking place in early gingivitis induced by ligature. The results of gene expression analysis indicated no changes for RECK. MMP-14 showed a reduction at 7 days of inflammation, and there was an immediate increase in MMP-2 gene expression and enzymatic activity, apparently by the stimulation of resident cells such as fibroblasts. A peak of MMP-9 expression 5 days after ligature followed after the peak of enzymatic activity found two days earlier. This pattern was consistent with the kinetics of macrophage and neutrophil recruitment. Immunohistochemistry suggested that MMP-9 was produced by both resident and inflammatory cells. Based on this evidence, it is suggested that extracellular matrix remodeling is related to MMP-2 and -9 production and activation. This allowed us to conclude that the host inflammatory response represents a significant factor for the advance of periodontal diseases. 24 157-66
Related items
Showing items related by title, author, creator and subject.
-
Optimal single-embryo mass spectrometry fingerprinting
Tata, Alessandra; Sudano, Mateus J.; Santos, Vanessa G.; Landim-Alvarenga, Fernanda D.C.; Ferreira, Christina R.; Eberlin, Marcos N. -
Optimal single-embryo mass spectrometry fingerprinting
Universidade Estadual de Campinas (UNICAMP); Universidade Estadual Paulista (UNESP) (2013-07-01)In pre-implantation embryos, lipids play key roles in determining viability, cryopreservation and implantation properties, but often their analysis is analytically challenging because of the few picograms of analytes present ... -
Convergence and computational efficiency enhancements in the iterative solution of the G-particle-hole hypervirial equation
Alcoba, Diego Ricardo; Tel, L. M.; Pérez Romero, E.; Valdemoro, C. (John Wiley & Sons Inc, 2011-04)The G-particle-hole hypervirial (GHV) equation has been recently reported (Valdemoro et al., Sixth International Congress of the International Society for Theoretical Chemical Physics Vancouver: Canada, 2008. Alcoba et ...