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Canine neutrophils activate effector mechanisms in response to Leishmania infantum
(2017-12-15)
Canine leishmaniosis caused by L. infantum is a severe zoonotic disease. Although macrophages are the definitive host cells, neutrophils are the first cells to encounter the parasite soon after its inoculation in the dermis ...
Platelets: New bricks in the building of neutrophil extracellular traps
(Frontiers Research Foundation, 2016-07)
In addition to being key elements in hemostasis and thrombosis, platelets have an important role in the inflammatory and innate immune response. This activity is associated with their capability to recognize pathogens ...
The role of neutrophils in severe sepsis
(LIPPINCOTT WILLIAMS & WILKINS, 2008)
Neutrophils are key effectors of the innate immune response. Reduction of neutrophil migration to infection sites is associated with a poor outcome in sepsis. We have demonstrated a failure of neutrophil migration in lethal ...
Role of inflammatory mediators in priming, activation, and deformability of bovine neutrophils
(Amer Veterinary Medical Assoc, 2000-05-01)
Objective-To determine the capacity of inflammatory mediators tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), platelet-activating factor (PAF), lipopolysaccharide (LPS), and leukotoxin to prime, activate, ...
Antimicrobial peptides and nitric oxide production by neutrophils from periodontitis subjects
(Associação Brasileira de Divulgação Científica, 2012)
Neutrophils play an important role in periodontitis by producing nitric oxide (NO) and antimicrobial peptides, molecules with microbicidal activity via oxygen-dependent and -independent mechanisms, respectively. It is ...
High concentrations of glucose reduce the oxidative metabolism of dog neutrophils in vitro
(2013-02-06)
Background: Dogs are commonly affected by hyperglycemic conditions. Hyperglycemia compromises the immune response and favors bacterial infections; however, reports on the effects of glucose on neutrophil oxidative metabolism ...
The uremic toxin methylguanidine increases the oxidative metabolism and accelerates the apoptosis of canine neutrophils
(2017-03-01)
We investigated the hypothesis that the increased concentration of plasma methylguanidine (MG) increases oxidative metabolism and accelerates apoptosis of neutrophils from dogs with chronic kidney disease (CKD). To achieve ...
Adoptive transfer of isolated bone marrow neutrophil
(Bio-protocol, 2012-05)
Adoptive transfer experiments of specific cell populations are widely used methods to assess the role of the injected population on an ongoing process. In the last years, new and unprecedented roles in the regulation of ...
Characterization of the anti-inflammatory capacity of IL-10-producing neutrophils in response to Streptococcus pneumoniae Infection
(Frontiers Media, 2021)
Neutrophils are immune cells classically defined as pro-inflammatory effector cells.
However, current accumulated evidence indicates that neutrophils have more versatile
immune-modulating properties. During acute lung ...
Modulation of γδ T-cell activation by neutrophil elastase
(Wiley Blackwell Publishing, Inc, 2017-09)
γδ T cells are non-conventional, innate-like T cells, characterized by a restricted T-cell receptor repertoire. They participate in protective immunity responses against extracellular and intracellular pathogens, tumour ...