Artículos de revistas
Family-based association study for bipolar affective disorder
Registro en:
Psychiatric Genetics. Lippincott Williams & Wilkins, v. 20, n. 3, n. 126, n. 129, 2010.
0955-8829
WOS:000278072700008
10.1097/YPG.0b013e32833a2050
Autor
Secolin, R
Banzato, CEM
Oliveira, MCM
Bittar, MFR
Santos, ML
Dalgalarrondo, P
Lopes-Cendes, I
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio = 2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences. Psychiatr Genet 20:126-129 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. 20 3 126 129 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) FAPESP [08/55827-9, 06/57332-1, 02/06831-7]