Family-based association study for bipolar affective disorder

dc.creatorSecolin, R
dc.creatorBanzato, CEM
dc.creatorOliveira, MCM
dc.creatorBittar, MFR
dc.creatorSantos, ML
dc.creatorDalgalarrondo, P
dc.creatorLopes-Cendes, I
dc.date2010
dc.dateJUN
dc.date2014-11-18T21:42:22Z
dc.date2015-11-26T17:54:34Z
dc.date2014-11-18T21:42:22Z
dc.date2015-11-26T17:54:34Z
dc.date.accessioned2018-03-29T00:38:16Z
dc.date.available2018-03-29T00:38:16Z
dc.identifierPsychiatric Genetics. Lippincott Williams & Wilkins, v. 20, n. 3, n. 126, n. 129, 2010.
dc.identifier0955-8829
dc.identifierWOS:000278072700008
dc.identifier10.1097/YPG.0b013e32833a2050
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/66754
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/66754
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/66754
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1290818
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionIn this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio = 2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences. Psychiatr Genet 20:126-129 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
dc.description20
dc.description3
dc.description126
dc.description129
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [08/55827-9, 06/57332-1, 02/06831-7]
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationPsychiatric Genetics
dc.relationPsychiatr. Genet.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectgenetics
dc.subjectmood disorders
dc.subjectpedigree disequilibrium test
dc.subjectsingle nucleotide polymorphisms
dc.subjectGenome-wide Association
dc.subjectGenetics
dc.subjectGenes
dc.subjectSusceptibility
dc.subjectMetaanalysis
dc.subjectLinkage
dc.subjectIndividuals
dc.subjectDepression
dc.subjectSupports
dc.subjectLoci
dc.titleFamily-based association study for bipolar affective disorder
dc.typeArtículos de revistas


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