Artículos de revistas
Endothelium-dependent coronary flow in ischemia reperfusion
Experimental And Toxicologic Pathology. Gustav Fischer Verlag, v. 49, n. 41671, n. 147, n. 151, 1997.
The aim of the present report was to study the effect of ischemia-reperfusion on the endothelial cell function of coronary vessels. Twelve adult male dogs were instrumented for the measurement of aortic and left ventricular pressures, heart rate and coronary blood flow. The left anterior descending coronary artery was occluded for 90 minutes followed by 20 minutes of reperfusion. Acetylcholine was infused into the coronary artery at a rate of 15 mu g/kg/min. Coronary flow, heart rate and aortic and left ventricular pressures were registered during the pre-occlusion period and after 20 minutes of reperfusion under basal conditions, as well as during acetylcholine administration. These same parameters were also measured during reactive hyperemia following vessel deocclusion. Acetylcholine produced a 155 % increasing coronary flow during the pre-occlusion period (p < 0.05). In the reperfusion period, no statistically significant difference was observed between the flows in the presence and absence of this substance, nor were there any differences in the other cardiovascular parameters monitored. Triphenyltetrazolium staining confirmed myocardial infarction in all the hearts examined. The authors conclude that reperfusion following myocardial infarction prevents the increasing in coronary flow in response to acetylcholine as a result of endothelial dysfunction in the resistance coronary vessels.4941671147151
Showing items related by title, author, creator and subject.
Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido? Ramalli Jr, Edvaldo Luiz; Braga, Leonardo Henrique; Evora, Patricia Martinez; Albuquerque, Agnes Afrodite Sumarelli; Celotto, Andrea Carla; Mota, André Lupp; Evora, Paulo Roberto Barbosa
Ausência de arteriosclerose na porção intramiocárdica das artérias coronárias: Um mistério a ser resolvido? Universidade de São Paulo (USP); Universidade Estadual Paulista (UNESP); Laboratory of Vascular Reactivity and Endothelial Function; Laboratory of Biomedical Vascular Reactivity and Endothelial Function; Universidade de São (2011-07-01)Several studies show that portions of intramyocardial coronary arteries are spared of arteriosclerosis, involving morphological, embryological, biochemical and pathophysiological aspects. Endothelial function is significantly ...
Echeverri Arcila, Darío (2017)