Severe distal cytomegalovirus esophagitis with aerodigestive symptoms in an immunocompetent infant

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorMachado, Nilton Carlos
dc.creatorCarvalho, Mary de Assis
dc.creatorOrtolan, Erika Veruska Paiva
dc.creatorRodrigues, Maria Aparecida Marchesan
dc.date2016-04-01T18:43:39Z
dc.date2016-10-25T21:36:17Z
dc.date2016-04-01T18:43:39Z
dc.date2016-10-25T21:36:17Z
dc.date2013
dc.date.accessioned2017-04-06T10:17:28Z
dc.date.available2017-04-06T10:17:28Z
dc.identifierInternational Journal of Clinical Pediatrics, v. 2, n. 1, p. 40-43, 2013.
dc.identifier1927-1255
dc.identifierhttp://hdl.handle.net/11449/136985
dc.identifierhttp://acervodigital.unesp.br/handle/11449/136985
dc.identifier10.4021/ijcp78w
dc.identifierISSN1927-1255-2013-02-01-40-43.pdf
dc.identifier6968547626233995
dc.identifierhttp://dx.doi.org/10.4021/ijcp78w
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/947507
dc.descriptionWe report a case of an immunocompetent infant, with no evidence of neurological disorders, which developed clinical manifestation of recurrent crisis of choking, dysphagia, laryngeal stridor and sub costal retractions since the first day of life. Direct laryngoscopy was unremarkable. Upper gastrointestinal series showed a dilated tortuous esophagus with severe peristalsis impairment and reflux episodes till the proximal third of the esophagus. An upper gastrointestinal endoscopy showed a moderately dilated esophagus with erosive lesions in the distal esophagus. Esophageal biopsy specimens revealed CMV inclusion bodies associated to moderate inflammation and immunohistochemistry was positive for CMV early antigen. Prolonged 24 h esophageal pH metry was within normal limits. Antiviral therapy with intravenous ganciclovir was introduced and was associated with rapid improvement of the symptoms. Child gradually increased oral intake and weight gain, and there were no side effects related to therapy. Thus, the respiratory symptoms could have been a supra esophageal manifestation of a non-acid reflux disease related to the CMV esophagitis.
dc.languageeng
dc.relationInternational Journal of Clinical Pediatrics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCytomegalovirus
dc.subjectEsophagitis
dc.subjectGanciclovir
dc.subjectImmunocompetent infant
dc.subjectImmunohistochemistry
dc.titleSevere distal cytomegalovirus esophagitis with aerodigestive symptoms in an immunocompetent infant
dc.typeOtro


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