dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCazedey, Edith Cristina Laignier
dc.creatorGarg, Sanjay
dc.creatorSalgado, Herida Regina Nunes
dc.date2016-01-28T16:56:38Z
dc.date2016-10-25T21:28:54Z
dc.date2016-01-28T16:56:38Z
dc.date2016-10-25T21:28:54Z
dc.date2013
dc.date.accessioned2017-04-06T09:50:27Z
dc.date.available2017-04-06T09:50:27Z
dc.identifierInternational Journal of Sciences, v. 2, n. 9, p. 11-20, 2013.
dc.identifier2305-3925
dc.identifierhttp://hdl.handle.net/11449/133796
dc.identifierhttp://acervodigital.unesp.br/handle/11449/133796
dc.identifier9881720291571774
dc.identifierhttp://www.ijsciences.com/pub/article/257#abstract
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/944325
dc.descriptionOrbifloxacin (ORBI) was subjected to different ICH (Q1A(R2)) prescribed stress conditions of thermal stress, hydrolysis, oxidation and photolysis. It was stable to dry heat (60 ºC) and photolysis (UV-VIS) in solid form. It showed extensive decomposition under hydrolytic and photolytic conditions in acid, base and neutral solutions. Degradation was also observed in oxidative condition. Degradation products of ORBI formed under different forced conditions were characterized through LC–MS studies. In total, eleven major degradation products (DP1-DP11) were detected. Successful separation of drug and degradation products formed under various stress conditions was achieved on a analytical column SymmetryShield Waters RP18, 5 µm, 250 x 4.6 mm using 5% acetic acid and methanol as mobile phase in a gradient mode at flow rate of 0.5 ml/min. The peaks were detected using a PDA detector set at 290 nm. The method was extended to LC–APCI-MS for characterization of the degradation products and the pathways of decomposition were proposed.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.relationInternational Journal of Sciences
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOrbifloxacin
dc.subjectChemistry degradation
dc.subjectSIAM
dc.subjectLC-APCI-MS
dc.subjectStability
dc.titleEvaluation and degradation chemistry of orbifloxacin using LC-MS
dc.typeOtro


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