Physico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCorrêa, Josilene Chaves Ruela
dc.creatorHiene, Marcelo Augusto Cavaretti
dc.creatorSalgado, Hérida Regina Nunes
dc.date2016-01-28T16:56:27Z
dc.date2016-10-25T21:28:47Z
dc.date2016-01-28T16:56:27Z
dc.date2016-10-25T21:28:47Z
dc.date2013
dc.date.accessioned2017-04-06T09:50:05Z
dc.date.available2017-04-06T09:50:05Z
dc.identifierJournal of Analytical & Bioanalytical Techniques, v. 5, n. 1, p. 1-6, 2013.
dc.identifier2155-9872
dc.identifierhttp://hdl.handle.net/11449/133745
dc.identifierhttp://acervodigital.unesp.br/handle/11449/133745
dc.identifier10.4172/2155-9872.1000177
dc.identifierISSN2155-9872-2013-05-01-01-06.pdf
dc.identifier9881720291571774
dc.identifier6036218587648028
dc.identifier9543471795910202
dc.identifierhttp://dx.doi.org/10.4172/2155-9872.1000177
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/944274
dc.descriptionSodium azumolene is a drug designed to fight Malignant Hyperthermia (MH), which is characterized by genetic predisposition and triggered by the use of inhalational anesthetics. This drug is shown as a water-soluble analogue of dantrolene sodium, 30-folds more water soluble, which gives advantages for its emergency use. To our knowledge there is no analytical method for sodium zaumolene raw material or dosage form published so far. The objective of the present investigation was to develop and validate analytical methods to achieve sodium azumolene chemical identification and quantification. The sodium azumolene was characterized regarding its thermal behavior, by differential thermal analysis and thermogravimetric analysis; Visible, UV and infrared absorption. To accurately assess the sodium Azumolene content three different analytical methods (visible and UV spectrophotometry and high performance liquid chromatography) were developed and validated. All methods showed to be linear, accurate, precise and reliable. Azumolene has shown to be equipotent to dantrolene in the treatment and prevention of an MH crisis and the great advantage compared to dantrolene is better water solubility. This study has characterized the sodium azumolene and presents new analytical methods which have not been reported so far.
dc.languageeng
dc.relationJournal of Analytical & Bioanalytical Techniques
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMalignant hyperthermia
dc.subjectSodium azumolene
dc.subjectUV-VIS
dc.subjectSpectrophotometry
dc.subjectLiquid chromatography
dc.subjectQuality control
dc.titlePhysico-chemical characterization and analytical development for sodium azumolene, a potential drug designed to fight malignant hyperthermia
dc.typeOtro


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