The homeostasis of iron, copper, and zinc in paracoccidioides brasiliensis, cryptococcus neoformans var. Grubii, and cryptococcus gattii: a comparative analysis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSilva, Merelle Garcia
dc.creatorSchrank, Augusto
dc.creatorBailão, Elisa Flávia L. C.
dc.creatorBailão, Alexandre Melo
dc.creatorBorges, Clayton Luiz
dc.creatorStaats, Charley Christian
dc.creatorParente, Juliana Alves
dc.creatorPereira, Maristela
dc.creatorIzaac, Silvia Maria Salem
dc.creatorMendes-Giannini, Maria José Soares
dc.creatorOliveira, Roseli Maria Zancopé
dc.creatorSilva, Livia K. Rosa e
dc.creatorNosanchuk, Joshua D.
dc.creatorVainstein, Marilene Henning
dc.creatorSoares, Célia Maria de Almeida
dc.date2016-01-28T16:56:17Z
dc.date2016-10-25T21:28:43Z
dc.date2016-01-28T16:56:17Z
dc.date2016-10-25T21:28:43Z
dc.date2011
dc.date.accessioned2017-04-06T09:49:53Z
dc.date.available2017-04-06T09:49:53Z
dc.identifierFrontiers in Microbiology, v. 2, n. 49, p. 1-19, 2011.
dc.identifier1664-302X
dc.identifierhttp://hdl.handle.net/11449/133713
dc.identifierhttp://acervodigital.unesp.br/handle/11449/133713
dc.identifier10.3389/fmicb.2011.00049
dc.identifier0000-0002-8059-0826
dc.identifier8972540207861201
dc.identifier0134821761458628
dc.identifier5415221996976886
dc.identifier8867708267053410
dc.identifier6238654594421708
dc.identifier1345781867765758
dc.identifier6034625575894077
dc.identifier1152828531273019
dc.identifier8539946335852637
dc.identifierhttp://dx.doi.org/10.3389/fmicb.2011.00049
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/944243
dc.descriptionIron, copper, and zinc are essential for all living organisms. Moreover, the homeostasis of these metals is vital to microorganisms during pathogenic interactions with a host. Most pathogens have developed specific mechanisms for the uptake of micronutrients from their hosts in order to counteract the low availability of essential ions in infected tissues. We report here an analysis of genes potentially involved in iron, copper, and zinc uptake and homeostasis in the fungal pathogens Paracoccidioides brasiliensis, Cryptococcus neoformans var. grubii, and Cryptococcus gattii. Although prior studies have identified certain aspects of metal regulation in Cryptococcus species, little is known regarding the regulation of these elements in P. brasiliensis. We also present amino acid sequences analyses of deduced proteins in order to examine possible conserved domains. The genomic data reveals, for the first time, genes associated to iron, copper, and zinc assimilation and homeostasis in P. brasiliensis. Furthermore, analyses of the three fungal species identified homologs to genes associated with high-affinity uptake systems, vacuolar and mitochondrial iron storage, copper uptake and reduction, and zinc assimilation. However, homologs to genes involved in siderophore production were only found in P. brasiliensis. Interestingly, in silico analysis of the genomes of P. brasiliensis Pb01, Pb03, and Pb18 revealed significant differences in the presence and/or number of genes involved in metal homeostasis, such as in genes related to iron reduction and oxidation. The broad analyses of the genomes of P. brasiliensis, C. neoformans var. grubii, and C. gattii for genes involved in metal homeostasis provide important groundwork for numerous interesting future areas of investigation that are required in order to validate and explore the function of the identified genes and gene pathways.
dc.languageeng
dc.relationFrontiers in Microbiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleThe homeostasis of iron, copper, and zinc in paracoccidioides brasiliensis, cryptococcus neoformans var. Grubii, and cryptococcus gattii: a comparative analysis
dc.typeOtro


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