Treatment of experimental periodontal disease by antimicrobial photodynamic therapy in nicotine-modified rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGarcia, Valdir Gouveia
dc.creatorFernades, Leandro Araújo
dc.creatorMacarini, Valmir Campos
dc.creatorAlmeida, Juliano Milanezi de
dc.creatorMartins, Thiago Marchi
dc.creatorBosco, Alvaro Francisco
dc.creatorNagata, Maria Jose Hitomi
dc.creatorCirelli, Joni Augusto
dc.creatorTheodoro, Letícia Helena
dc.date2016-01-28T16:55:48Z
dc.date2016-10-25T21:28:27Z
dc.date2016-01-28T16:55:48Z
dc.date2016-10-25T21:28:27Z
dc.date2011
dc.date.accessioned2017-04-06T09:49:00Z
dc.date.available2017-04-06T09:49:00Z
dc.identifierJournal of Clinical Periodontology, v. 38, p. 1106-1114, 2011.
dc.identifier0303-6979
dc.identifierhttp://hdl.handle.net/11449/133602
dc.identifierhttp://acervodigital.unesp.br/handle/11449/133602
dc.identifier10.1111/j.1600-051X.2011.01785.x
dc.identifier4774447118127346
dc.identifier4068921369233125
dc.identifier0047062193534190
dc.identifier0939609150485625
dc.identifier9831236034935598
dc.identifier8399870097572073
dc.identifier2628593693450121
dc.identifierhttp://dx.doi.org/10.1111/j.1600-051X.2011.01785.x
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/944132
dc.descriptionBackground The aim of this study was to compare antimicrobial photodynamic therapy (aPDT) as an adjunctive treatment to scaling and root planing (SRP) for induced periodontitis in nicotine-modified rats. Material & Methods A total of 240 rats were evenly divided into two groups: C – saline solution treatment; N – nicotine treatment. Periodontal disease was induced in both groups at the first mandibular molar. After 7 days, the ligature was removed. All animals were submitted to SRP and were divided according to the following treatments: SRP – irrigation with saline solution; Toluidine Blue-O (TBO) – irrigation with phenothiazinium dye (100 μg/ml); LLLT – laser irradiation (660 nm; 0.03 W; 4 J); and aPDT – TBO and laser irradiation. Ten animals in each group/treatment were euthanized at 7, 15 and 30 days. The histometric and immunohistochemical values were statistically analysed. Results Intragroup analysis demonstrated that in both groups the aPDT treatment resulted in lower bone loss (BL) when compared to SRP in all experimental periods. Intergroup analysis demonstrated that aPDT treatment resulted in lower BL in Group N than in Group C treated with SRP in all experimental periods. Conclusion Antimicrobial photodynamic therapy was an effective adjunctive treatment to SRP for induced periodontitis in nicotine-modified rats.
dc.languageeng
dc.relationJournal of Clinical Periodontology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlveolar bone loss
dc.subjectLasers
dc.subjectnicotine
dc.subjectOsteoclasts
dc.subjectPeriodontitis
dc.subjectPhotochemotherapy
dc.titleTreatment of experimental periodontal disease by antimicrobial photodynamic therapy in nicotine-modified rats
dc.typeOtro


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