Clonidine and phenylephrine injected into the lateral preoptic area reduce water intake in dehydrated rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCallera, João Carlos
dc.creatorCamargo, Luiz Antonio de Arruda
dc.creatorLuca Junior, Laurival Antonio de
dc.creatorMenani, José Vanderlei
dc.creatorRenzi, Antonio
dc.creatorSaad, Wilson Abrão
dc.date2014-05-27T11:17:53Z
dc.date2016-10-25T21:25:32Z
dc.date2014-05-27T11:17:53Z
dc.date2016-10-25T21:25:32Z
dc.date1993-09-01
dc.date.accessioned2017-04-06T09:38:09Z
dc.date.available2017-04-06T09:38:09Z
dc.identifierPharmacology, Biochemistry and Behavior, v. 46, n. 1, p. 39-43, 1993.
dc.identifier0091-3057
dc.identifierhttp://hdl.handle.net/11449/132311
dc.identifierhttp://acervodigital.unesp.br/handle/11449/132311
dc.identifier10.1016/0091-3057(93)90314-J
dc.identifierWOS:A1993LY41300007
dc.identifier2-s2.0-0027420310
dc.identifierhttp://dx.doi.org/10.1016/0091-3057(93)90314-J
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/942851
dc.descriptionIn the present study, we investigated the effect of phenylephrine and clonidine (α1- and α2-adrenoceptor agonists, respectively) injected into the lateral preoptic area (LPOA) on the water intake induced by water deprivation in rats. In addition, the effects of prior injections of prazosin and yohimbine (α1- and α2-adrenoceptor antagonists, respectively) into the LPOA on the antidipsogenic action of phenylephrine and clonidine were investigated. After 30 h of water deprivation, the water intake of rats in a control experiment (saline injection) was 10.5 ± 0.8 ml/h. Injection of clonidine (5, 10, 20, and 40 nmol) into the LPOA reduced water intake to 6.3 ± 0.9, 4.9 ± 0.8, 3.6 ± 1.0, and 2.2 ± 0.7 ml/h, respectively. Similar reductions occurred after injection of 80 and 160 nmol phenylephrine into the LPOA (6.2 ± 1.6 and 4.8 ± 1.3 ml/h, respectively). Pretreatment with prazosin (40 nmol) abolished the antidipsogenic action of an 80-nmol dose of phenylephrine (11.3 ± 1.1 ml/h) and reduced the effect of a 20-nmol dose of clonidine (7.4 ± 1.4 ml/h). Yohimbine (20, 40, and 80 nmol), previously injected, produced no significant changes in the effects of either phenylephrine or clonidine. The present results show that phenylephrine and clonidine injected into the LPOA induce an antidipsogenic effect in water-deprived rat. They also suggest an involvement of α1-adrenoceptors in this effect. A possible participation of imidazole receptors in the effect of clonidine should also be taken into account. © 1993.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPharmacology Biochemistry and Behavior
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectα-Adrenoceptors
dc.subjectClonidine
dc.subjectPreoptic area
dc.subjectThirst
dc.subjectWater intake
dc.subjectAlpha 1 adrenergic receptor
dc.subjectAlpha 1 adrenergic receptor blocking agent
dc.subjectAlpha 1 adrenergic receptor stimulating agent
dc.subjectAlpha 2 adrenergic receptor blocking agent
dc.subjectAlpha 2 adrenergic receptor stimulating agent
dc.subjectClonidine
dc.subjectPhenylephrine
dc.subjectPrazosin
dc.subjectYohimbine
dc.subjectAnimal experiment
dc.subjectAnimal tissue
dc.subjectControlled study
dc.subjectDehydration
dc.subjectDrug antagonism
dc.subjectFluid intake
dc.subjectHistology
dc.subjectIntracerebral drug administration
dc.subjectMale
dc.subjectNonhuman
dc.subjectPreoptic area
dc.subjectPriority journal
dc.subjectRat
dc.subjectThirst
dc.subjectAdrenergic alpha-Agonists
dc.subjectAnimal
dc.subjectDehydration
dc.subjectDrinking Behavior
dc.subjectInjections
dc.subjectMale
dc.subjectPhenylephrine
dc.subjectPrazosin
dc.subjectPreoptic Area
dc.subjectRats
dc.subjectReceptors, Adrenergic, alpha-1
dc.subjectReceptors, Adrenergic, alpha-2
dc.subjectSupport, Non-U.S. Gov't
dc.subjectYohimbine
dc.titleClonidine and phenylephrine injected into the lateral preoptic area reduce water intake in dehydrated rats
dc.typeOtro


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