Chromosome aberrations in lymphocyte cultures from paracoccidioidomycosis patients

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFreire-Maia, D. V.
dc.creatorGarcia, M. G.
dc.creatorMendes, R. P.
dc.creatorMarques, S. A.
dc.creatorCuri, P. R.
dc.creatorSouza, L. R.
dc.date2014-05-27T11:17:57Z
dc.date2016-10-25T21:25:31Z
dc.date2014-05-27T11:17:57Z
dc.date2016-10-25T21:25:31Z
dc.date1994-07-21
dc.date.accessioned2017-04-06T09:38:07Z
dc.date.available2017-04-06T09:38:07Z
dc.identifierJournal of Medical and Veterinary Mycology, v. 32, n. 3, p. 199-203, 1994.
dc.identifier0268-1218
dc.identifierhttp://hdl.handle.net/11449/132306
dc.identifierhttp://acervodigital.unesp.br/handle/11449/132306
dc.identifier10.1080/02681219480000261
dc.identifierWOS:A1994NU15600005
dc.identifier2-s2.0-0028064743
dc.identifierhttp://dx.doi.org/10.1080/02681219480000261
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/942846
dc.descriptionBlood cell lymphocyte chromosomes from untreated (UT) and clinically-cured (CC) patients with paracoccidioidomycosis and from healthy (control) people (CO) were studied. The frequency of aneuploid cells in the UT patients was higher than in the CC and CO individuals. The frequency of metaphase cells with premature centromere division was significantly higher in the UT than in the CC and CO group. No structural aberration and no statistically significant difference in the frequency of polyploidy was observed in the three groups studied. Our findings are indicative of an aneugenic (aneuploidy-inducing) action of infection by Paracoccidioides brasiliensis.
dc.languageeng
dc.publisherBlackwell Science
dc.relationJournal of Medical and Veterinary Mycology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdult
dc.subjectAneuploidy
dc.subjectChromosome aberration
dc.subjectControlled study
dc.subjectHuman
dc.subjectHuman cell
dc.subjectLymphocyte culture
dc.subjectMajor clinical study
dc.subjectMale
dc.subjectMetaphase
dc.subjectMycosis
dc.subjectPolyploidy
dc.subjectSouth american blastomycosis
dc.subjectAdult
dc.subjectChromosome Aberrations
dc.subjectFemale
dc.subjectHuman
dc.subjectLymphocytes
dc.subjectMale
dc.subjectMetaphase
dc.subjectMiddle Age
dc.subjectParacoccidioidomycosis
dc.subjectPloidies
dc.subjectSupport, Non-U.S. Gov't
dc.titleChromosome aberrations in lymphocyte cultures from paracoccidioidomycosis patients
dc.typeOtro


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