A dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPedrolli, Danielle Biscaro
dc.creatorKühm, Christian
dc.creatorSévin, Daniel C.
dc.creatorVockenhuber, Michael P.
dc.creatorSauer, Uwe
dc.creatorSuess, Beatrix
dc.creatorMack, Matthias
dc.date2015-12-07T15:39:40Z
dc.date2016-10-25T21:24:04Z
dc.date2015-12-07T15:39:40Z
dc.date2016-10-25T21:24:04Z
dc.date2015-10-22
dc.date.accessioned2017-04-06T09:32:31Z
dc.date.available2017-04-06T09:32:31Z
dc.identifierProceedings Of The National Academy Of Sciences Of The United States Of America, p. 14054–14059, 2015.
dc.identifier1091-6490
dc.identifierhttp://hdl.handle.net/11449/131658
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131658
dc.identifier10.1073/pnas.1515024112
dc.identifier0000-0002-3034-6497
dc.identifier26494285
dc.identifierhttp://dx.doi.org/10.1073/pnas.1515024112
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/942198
dc.descriptionFlavin mononucleotide (FMN) riboswitches are genetic elements, which in many bacteria control genes responsible for biosynthesis and/or transport of riboflavin (rib genes). Cytoplasmic riboflavin is rapidly and almost completely converted to FMN by flavokinases. When cytoplasmic levels of FMN are sufficient (high levels), FMN binding to FMN riboswitches leads to a reduction of rib gene expression. We report here that the protein RibR counteracts the FMN-induced turn-off activities of both FMN riboswitches in Bacillus subtilis, allowing rib gene expression even in the presence of high levels of FMN. The reason for this secondary metabolic control by RibR is to couple sulfur metabolism with riboflavin metabolism.
dc.languageeng
dc.relationProceedings Of The National Academy Of Sciences Of The United States Of America
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBacillus subtilis
dc.subjectFmn riboswitch
dc.subjectRibr
dc.subjectFlavin mononucleotide
dc.subjectRiboflavin
dc.titleA dual control mechanism synchronizes riboflavin and sulphur metabolism in Bacillus subtilis
dc.typeOtro


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