Diretrizes de conduta e tratamento de síndromes febris periódicas: síndrome de febre periódica, estomatite aftosa, faringite e adenite

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTerreri, Maria Teresa R A
dc.creatorBernardo, Wanderley Marques
dc.creatorLen, Claudio Arnaldo
dc.creatorSilva, Clovis Artur Almeida da
dc.creatorMagalhães, Cristina Medeiros Ribeiro de
dc.creatorSacchetti, Silvana B.
dc.creatorFerriani, Virgínia Paes Leme
dc.creatorPiotto, Daniela Gerent Petry
dc.creatorCavalcanti, André de Souza
dc.creatorMoraes, Ana Júlia Pantoja de
dc.creatorSztajnbok, Flavio Roberto
dc.creatorOliveira, Sheila Knupp Feitosa de
dc.creatorCampos, Lucia Maria Arruda
dc.creatorBandeira, Marcia
dc.creatorSantos, Flávia Patricia Sena Teixeira
dc.creatorMagalhães, Claudia Saad
dc.date2015-12-07T15:38:44Z
dc.date2016-10-25T21:23:58Z
dc.date2015-12-07T15:38:44Z
dc.date2016-10-25T21:23:58Z
dc.date2015-10-01
dc.date.accessioned2017-04-06T09:32:07Z
dc.date.available2017-04-06T09:32:07Z
dc.identifierRevista Brasileira De Reumatologia, 2015.
dc.identifier1809-4570
dc.identifierhttp://hdl.handle.net/11449/131616
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131616
dc.identifier10.1016/j.rbr.2015.08.005
dc.identifier26498845
dc.identifierhttp://dx.doi.org/10.1016/j.rbr.2015.08.005
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/942156
dc.descriptionTo establish guidelines based on scientific evidence for the management of periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. The Guideline was prepared from 5 clinical questions that were structured through PICO (Patient, Intervention or indicator, Comparison and Outcome), to search in key primary scientific information databases. After defining the potential studies to support the recommendations, these were graduated considering their strength of evidence and grade of recommendation. 806 articles were retrieved and evaluated by title and abstract; from these, 32 articles were selected to support the recommendations. 1. PFAPA is a diagnosis of exclusion established on clinical grounds, and one must suspect of this problem in children with recurrent and periodic febrile episodes of unknown origin, or with recurrent tonsillitis interspersed with asymptomatic periods, especially in children in good general condition and with preservation of weight and height development; 2. Laboratory findings are nonspecific. Additional tests do not reveal pathognomonic changes; 3. The evidence supporting an indication for surgical treatment (tonsillectomy with or without adenoidectomy), is based on two non-blinded randomized clinical trials with small numbers of patients; 4. The use of prednisone at the onset of fever in patients with PFAPA proved to be an effective strategy. There is still need for more qualified evidence to support its use in patients with PFAPA; 5. Despite promising results obtained in studies with IL-1ß inhibitors, such studies are limited to a few case reports.
dc.descriptionObjetivo Estabelecer diretrizes baseadas em evidências científicas para manejo da síndrome de febre periódica, estomatite aftosa, faringite e adenite (PFAPA). Descrição do método de coleta de evidência A Diretriz foi elaborada a partir de cinco questões clínicas que foram estruturadas por meio do Pico (Paciente, Intervenção ou Indicador, Comparação e Outcome), com busca nas principais bases primárias de informação científica. Após definir os estudos potenciais para sustento das recomendações, esses foram graduados pela força da evidência e pelo grau de recomendação. Resultados Foram recuperados e avaliados pelo título e resumo 806 trabalhos e selecionados 32 artigos, para sustentar as recomendações.
dc.languagepor
dc.publisherElsevier B. V.
dc.relationRevista Brasileira De Reumatologia
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAutoinflammatory syndromes
dc.subjectChildhood
dc.subjectDiretrizes
dc.subjectFebre
dc.subjectFever
dc.subjectGuidelines
dc.subjectInfância
dc.subjectSyndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis
dc.subjectSíndrome de febre periódica, estomatite aftosa, faringite e adenite cervical
dc.subjectSíndromes autoinflamatórias
dc.titleDiretrizes de conduta e tratamento de síndromes febris periódicas: síndrome de febre periódica, estomatite aftosa, faringite e adenite
dc.typeOtro


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