Susceptibility of helminth species from horses against different chemical compounds in Brazil

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFelippelli, Gustavo
dc.creatorCruz, Breno Cayeiro
dc.creatorGomes, Lucas Vinicius Costa
dc.creatorLopes, Welber Daniel Zanetti
dc.creatorTeixeira, Weslen Fabrício Pires
dc.creatorMaciel, Willian Giquelin
dc.creatorBuzzulini, Carolina
dc.creatorBichuette, Murilo Abud
dc.creatorCampos, Gabriel Pimentel
dc.creatorSoares, Vando Edésio
dc.creatorBergamasco, Paula Luzia Formigoni
dc.creatorOliveira, Gilson Pereira de
dc.creatorCosta, Alvimar José da
dc.date2015-12-07T15:38:05Z
dc.date2016-10-25T21:23:53Z
dc.date2015-12-07T15:38:05Z
dc.date2016-10-25T21:23:53Z
dc.date2015-09-15
dc.date.accessioned2017-04-06T09:31:49Z
dc.date.available2017-04-06T09:31:49Z
dc.identifierVeterinary Parasitology, v. 212, n. 3-4, p. 232-238, 2015.
dc.identifier1873-2550
dc.identifierhttp://hdl.handle.net/11449/131584
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131584
dc.identifier10.1016/j.vetpar.2015.07.041
dc.identifier26277565
dc.identifierhttp://dx.doi.org/10.1016/j.vetpar.2015.07.041
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/942124
dc.descriptionBy means of parasitological necropsies, the present study aimed to evaluate, in six experiments, the degree of susceptibility or resistance of different helminth species which naturally infect horses to ivermectin 0.2mg/kg, abamectin 0.2mg/kg, moxidectin 0.4mg/kg, trichlorfon 35mg/kg, ivermectin 0.2mg/kg+praziquantel 2.5mg/kg, abamectin 0.2mg/kg+praziquantel 2.5mg/kg and ivermectin 0.2mg/kg+6.6 mg/kg pyrantel. At experimental day zero, the horses were allocated to treatment groups based on average counts of strongylid eggs per gram of feces (EPG) obtained on days -3, -2 and -1. Oxyuris sp. infections were confirmed as positive or negative. All the animals in the six experiments were naturally infected by this helminth species. Each group (control or treated) consisted of six animals. All the assessed Habronema muscae populations analyzed were susceptible to ivermectin, abamectin and moxidectin. Of the six Trichostrongylus axei populations, four were susceptible to ivermectin, abamectin, moxidectin, trichlorfon and ivermectin+praziquantel, and two were resistant to abamectin+praziquantel and ivermectin+pyrantel. Both Strongyloides westeri populations analyzed were susceptible to ivermectin, abamectin, moxidectin and abamectin+praziquantel. For O. equi, resistance was found in four different populations treated with ivermectin, abamectin, moxidectin, trichlorfon and ivermectin+praziquantel. Only combinations of abamectin+praziquantel and ivermectin+pyrantel were effective against this parasite species. All the large strongyles diagnosed in the present study (Strongyus edentatus, Strongyus vulgaris and Triodontophorus serratus) were susceptible to all the chemicals tested, with the exception of trichlorfon. Of the Cyathostominae populations, one was diagnosed as resistant to ivermectin and another to trichlorfon. The remaining populations from this nematode group were considered to be sensitive to ivermectin, abamectin, moxidectin, ivermectin+praziquantel, abamectin+praziquantel and ivermectin+pyrantel. New studies should be performed in different regions to evaluate the efficacy of trichlorfon in others field populations of helminthes.
dc.languageeng
dc.publisherElsevier B. V.
dc.relationVeterinary Parasitology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAnthelmintic resistance
dc.subjectDrugs
dc.subjectEfficacy
dc.subjectHorses
dc.titleSusceptibility of helminth species from horses against different chemical compounds in Brazil
dc.typeOtro


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