Increased DNA damage is related to maternal blood glucose levels in the offspring of women with diabetes and mild gestational hyperglycemia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGelaleti, Rafael Bottaro
dc.creatorDamasceno, Débora C.
dc.creatorSantos, Daniele P.
dc.creatorCalderon, Iracema M P
dc.creatorRudge, Marilza Vieira Cunha
dc.date2015-12-07T15:37:32Z
dc.date2016-10-25T21:23:49Z
dc.date2015-12-07T15:37:32Z
dc.date2016-10-25T21:23:49Z
dc.date2015-09-02
dc.date.accessioned2017-04-06T09:31:32Z
dc.date.available2017-04-06T09:31:32Z
dc.identifierReproductive Sciences (thousand Oaks, Calif.), p. 771–775, 2015.
dc.identifier1933-7205
dc.identifierhttp://hdl.handle.net/11449/131555
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131555
dc.identifier10.1177/1933719115602766
dc.identifier0000-0002-9227-832X
dc.identifier26335178
dc.identifierhttp://dx.doi.org/10.1177/1933719115602766
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/942095
dc.descriptionThis study aimed at correlating maternal blood glucose levels with DNA damage levels in the offspring of women with diabetes or mild gestational hyperglycemia (MGH). Based on oral glucose tolerance test results and glycemic profiles, 56 pregnant women were allocated into 3 groups: nondiabetes, MGH, and diabetes. The offspring of these women (56 infants) were also evaluated. Maternal peripheral blood and umbilical cord blood samples were collected and processed for biochemical and DNA damage analysis by the comet assay. A positive correlation between maternal blood glucose mean and increased offspring DNA damage levels was observed. Hyperglycemia played a role in offspring DNA damage, but other diabetes-induced complications were also involved. Increased maternal blood glucose levels can lead to increased offspring DNA damage levels. Therefore, the monitoring, control, and treatment of pregnant women with diabetes and MGH are highly important to ensure a risk-free pregnancy and healthy infants.
dc.languageeng
dc.relationReproductive Sciences (thousand Oaks, Calif.)
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDna damage
dc.subjectDiabetes
dc.subjectMild gestational hyperglycemia
dc.subjectNewborns
dc.subjectPregnant women
dc.titleIncreased DNA damage is related to maternal blood glucose levels in the offspring of women with diabetes and mild gestational hyperglycemia
dc.typeOtro


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