Amoxicillin diminishes the thickness of the enamel matrix that is deposited during the secretory stage in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSouza, Juliana Feltrin de
dc.creatorGramasco, Marina
dc.creatorJeremias, Fabiano
dc.creatorSantos-Pinto, Lourdes
dc.creatorGiovanini, Allan Fernando
dc.creatorCerri, Paulo Sérgio
dc.creatorCordeiro, Rita de Cássia Loiola
dc.date2015-12-07T15:32:23Z
dc.date2016-10-25T21:22:56Z
dc.date2015-12-07T15:32:23Z
dc.date2016-10-25T21:22:56Z
dc.date2015
dc.date.accessioned2017-04-06T09:28:11Z
dc.date.available2017-04-06T09:28:11Z
dc.identifierInternational Journal Of Paediatric Dentistry / The British Paedodontic Society [and] The International Association Of Dentistry For Children, 2015.
dc.identifier1365-263X
dc.identifierhttp://hdl.handle.net/11449/131185
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131185
dc.identifier10.1111/ipd.12184
dc.identifier26148818
dc.identifierhttp://dx.doi.org/10.1111/ipd.12184
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/941725
dc.descriptionThe use of amoxicillin during early childhood has been associated with molar incisor hypomineralization. The objective of this study was to determine whether the use of amoxicillin interferes with enamel development, during secretion and early mineralization stages. Fifteen pregnant rats were randomly assigned to three groups that received physiological solution (sham group), 100 mg/kg/day amoxicillin (A100G), and 500 mg/kg/day amoxicillin (A500G). After birth, the pups in each group received the same treatment until post-natal day 7 or 12. The upper first molars were analyzed histomorphometrical and immunostaining with amelogenin on day 7, and MMP-20 on day 12 was performed using a semiquantitative method (H-score). At 7 days, several vacuolar structures were observed in the ameloblasts in the A100G and A500G groups. A significant reduction of the enamel thickness (P < 0.001) was found in amoxicillin-treated rats compared with the sham group. Significant differences were not observed in enamel thickness (P > 0.05) between the groups of 12-day-old rats. Moreover, significant differences were not observed in the number of amelogenin- and MMP-20-immunolabeled ameloblasts (P > 0.05) between groups. The present results suggest that amoxicillin interferes with the initial stages of amelogenesis by causing structural changes in the ameloblasts and a reduction of the enamel matrix.
dc.languageeng
dc.publisherWiley-Blackwell
dc.relationInternational Journal Of Paediatric Dentistry / The British Paedodontic Society [and] The International Association Of Dentistry For Children
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleAmoxicillin diminishes the thickness of the enamel matrix that is deposited during the secretory stage in rats
dc.typeOtro


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