Aging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: a systematic review of the literature

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPolettini, J.
dc.creatorDutta, E. H.
dc.creatorBehnia, F.
dc.creatorSaade, G. R.
dc.creatorTorloni, M. R.
dc.creatorMenon, R.
dc.date2015-12-07T15:31:35Z
dc.date2016-10-25T21:22:44Z
dc.date2015-12-07T15:31:35Z
dc.date2016-10-25T21:22:44Z
dc.date2015
dc.date.accessioned2017-04-06T09:27:28Z
dc.date.available2017-04-06T09:27:28Z
dc.identifierPlacenta, v. 36, n. 9, p. 969-973, 2015.
dc.identifier1532-3102
dc.identifierhttp://hdl.handle.net/11449/131100
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131100
dc.identifier10.1016/j.placenta.2015.05.003
dc.identifier26004735
dc.identifierhttp://dx.doi.org/10.1016/j.placenta.2015.05.003
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/941640
dc.descriptionMany adverse pregnancy outcomes (APOs), including spontaneous preterm birth (PTB), are associated with placental dysfunction. Recent clinical and experimental evidences suggest that premature aging of the placenta may be involved in these events. Although placental aging is a well-known concept, the mechanisms of aging during normal pregnancy and premature aging in APOs are still unclear. This review was conducted to assess the knowledge on placental aging related biochemical changes leading to placental dysfunction in PTB and/or preterm premature rupture of membranes (pPROM). We performed a systematic review of studies published over the last 50 years in two electronic databases (Pubmed and Embase) on placental aging and PTB or pPROM. The search yielded 554 citations, 30 relevant studies were selected for full-text review and three were included in the review. Only one study reported oxidative stress-related aging and degenerative changes in human placental membranes and telomere length reduction in fetal cells as part of PTB and/or pPROM mechanisms. Similarly, two animal studies reported findings of decidual senescence and referred to PTB mechanisms. Placental and fetal membrane oxidative damage and telomere reduction are linked to premature aging in PTB and pPROM but the risk factors and biomolecular pathways causing this phenomenon are not established in the literature. However, no biomarkers or clinical indicators of premature aging as a pathology of PTB and pPROM have been reported. We document major knowledge gaps and propose several areas for future research to improve our understanding of premature aging linked to placental dysfunction.
dc.languageeng
dc.publisherElsevier B. V.
dc.relationPlacenta
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdverse pregnancy outcome
dc.subjectAging
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectPrematurity
dc.subjectSenescence
dc.subjectTelomere length
dc.titleAging of intrauterine tissues in spontaneous preterm birth and preterm premature rupture of the membranes: a systematic review of the literature
dc.typeOtro


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