Orexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFonseca, Elisa M.
dc.creatorDias, Mirela B.
dc.creatorBícego, Kênia C.
dc.creatorGargaglioni, Luciane H.
dc.date2015-12-07T15:31:18Z
dc.date2016-10-25T21:22:39Z
dc.date2015-12-07T15:31:18Z
dc.date2016-10-25T21:22:39Z
dc.date2014-11-27
dc.date.accessioned2017-04-06T09:27:10Z
dc.date.available2017-04-06T09:27:10Z
dc.identifierRespiratory Physiology & Neurobiology, 2014.
dc.identifier1878-1519
dc.identifierhttp://hdl.handle.net/11449/131066
dc.identifierhttp://acervodigital.unesp.br/handle/11449/131066
dc.identifier10.1016/j.resp.2014.11.014
dc.identifier25434286
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2014.11.014
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/941606
dc.descriptionRecent reports have suggested that orexins, also known as hypocretins, play an important role in the modulation of respiratory control in mammals, but there are no data available describing the role of the orexinergic system in the peripheral and central chemoreception of non-mammalian vertebrates. Therefore, the present study was designed to examine the localization of orexin-immunoreactive neurons in the brain of toads (Rhinella schneideri) and to investigate the contribution of orexin receptor-1 (OX1R) to the hypoxic and hypercarbic ventilatory responses of these animals during light and dark phases. Our results demonstrated that the orexinergic neurons of R. schneideri are located in the suprachiasmatic nucleus of the diencephalon. Additionally, the intracerebroventricular injection of SB-334867 (OX1R selective antagonist) attenuated the ventilatory response to hypercarbia during the dark phase by acting on tidal volume and breathing frequency, while during the light phase, SB-334867 attenuated the ventilatory response to hypoxia by acting on tidal volume only. We conclude that in the toad R. schneideri, orexinergic neurons are located in the suprachiasmatic nucleus and that OX1R contributes to hypercarbic and hypoxic chemoreflexes.
dc.languageeng
dc.publisherElsevier B. V.
dc.relationRespiratory Physiology & Neurobiology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAmphibian
dc.subjectCo(2)
dc.subjectChemoreception
dc.subjectHypocretin
dc.subjectVentilation
dc.titleOrexin in the toad Rhinella schneideri: The location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia
dc.typeOtro


Este ítem pertenece a la siguiente institución