Clinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorGama, Carlos R. B.
dc.creatorLasmar, Ricardo
dc.creatorGama, Gustavo F.
dc.creatorAbreu, Camila S.
dc.creatorNunes, Carlos P.
dc.creatorGeller, Mauro
dc.creatorOliveira, Lisa
dc.creatorSantos, Alessandra
dc.date2015-12-07T15:30:32Z
dc.date2016-10-25T21:22:26Z
dc.date2015-12-07T15:30:32Z
dc.date2016-10-25T21:22:26Z
dc.date2014
dc.date.accessioned2017-04-06T09:26:25Z
dc.date.available2017-04-06T09:26:25Z
dc.identifierClinical Medicine Insights. Women's Health, v. 7, p. 45-50, 2014.
dc.identifier1179-562X
dc.identifierhttp://hdl.handle.net/11449/130974
dc.identifierhttp://acervodigital.unesp.br/handle/11449/130974
dc.identifier10.4137/CMWH.S17853
dc.identifierPMC4275110.pdf
dc.identifier25574150
dc.identifierPMC4275110
dc.identifierhttp://dx.doi.org/10.4137/CMWH.S17853
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/941514
dc.descriptionThis is a qualitative-quantitative study based on hospital records of female patients of reproductive age, presenting sexual dysfunction, and treated with 250 mg Tribulus terrestris extract (1 tablet thrice daily for 90 days). Safety monitoring included vital signs, physical examination, laboratory tests, and occurrence of adverse events. Efficacy analysis included results of the Female Sexual Function Index (FSFI), dehydroepiandrosterone (DHEA) levels together with total and free testosterone, and the patient and physician assessments. There was a statistically significant improvement in total FSFI scores (P < 0.0001) post-treatment, with improvement among 106 (88.33%) subjects. There was a statistically significant (P < 0.0001) increase in the level of DHEA, while the levels of both serum testosterone (P = 0.284) and free testosterone decreased (P < 0.0001). Most adverse events recorded were related to the gastrointestinal tract. Physical examination showed no significant changes post-treatment. Based on the results, it is concluded that the T. terrestris extract is safe and effective in the treatment of female sexual dysfunction.
dc.languageeng
dc.publisherLibertas Academica Ltd
dc.relationClinical Medicine Insights. Women's Health
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTribulus terrestris
dc.subjectFemale sexual dysfunction
dc.subjectFemale sexual function index
dc.titleClinical Assessment of Tribulus terrestris Extract in the Treatment of Female Sexual Dysfunction
dc.typeOtro


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