| dc.contributor | Universidade Estadual Paulista (UNESP) | |
| dc.creator | Minicucci, Marcos F. | |
| dc.creator | Azevedo, Paula S. | |
| dc.creator | Polegato, Bertha F. | |
| dc.creator | Paiva, Sergio A. R. | |
| dc.creator | Zornoff, Leonardo A. M. | |
| dc.date | 2015-12-07T15:30:09Z | |
| dc.date | 2016-10-25T21:22:18Z | |
| dc.date | 2015-12-07T15:30:09Z | |
| dc.date | 2016-10-25T21:22:18Z | |
| dc.date | 2012 | |
| dc.date.accessioned | 2017-04-06T09:25:55Z | |
| dc.date.available | 2017-04-06T09:25:55Z | |
| dc.identifier | Inflammation & Allergy Drug Targets, v. 11, n. 6, p. 442-447, 2012. | |
| dc.identifier | 2212-4055 | |
| dc.identifier | http://hdl.handle.net/11449/130916 | |
| dc.identifier | http://acervodigital.unesp.br/handle/11449/130916 | |
| dc.identifier | 22680625 | |
| dc.identifier | http://www.ncbi.nlm.nih.gov/pubmed/22680625 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/941456 | |
| dc.description | Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke exposure is recognized as one of these insults. Indeed, tobacco smoke exposure induces the enlargement of the left-sided cardiac chambers, myocardial hypertrophy, and ventricular dysfunction. Potential mechanisms for these alterations include hemodynamic and neurohormonal changes, oxidative stress, inflammation, nitric oxide bioavailability, matrix metalloproteinases and mitogen-activated protein kinase activation. This review will focus on the concepts, relevance, and potential mechanisms of cardiac remodeling induced by tobacco smoke. | |
| dc.language | eng | |
| dc.publisher | Inflammation & Allergy Drug Targets | |
| dc.relation | Inflammation & Allergy Drug Targets | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.subject | Matrix metalloproteinases | |
| dc.subject | Oxidative stress | |
| dc.subject | Tobacco smoke exposure | |
| dc.subject | Ventricular remodeling | |
| dc.subject | Cardiac Remodeling | |
| dc.subject | Heart size | |
| dc.subject | Myocardial hypertrophy | |
| dc.subject | Ventricular dysfunction | |
| dc.subject | Hemodynamic | |
| dc.subject | Neurohormonal changes | |
| dc.subject | Oxidative stress | |
| dc.subject | Inflammation | |
| dc.subject | Mitogen-activated protein kinase activation | |
| dc.title | Cardiac remodeling induced by smoking: concepts, relevance, and potential mechanisms | |
| dc.type | Otro | |
