Effect of furosemide treatment on the central and peripheral pressor responses to cholinergic and adrenergic agonists, angiotensin II, hypertonic solution and vasopressin

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorColombari, Débora Simões de Almeida
dc.creatorColombari, Eduardo
dc.creatorSaad, Wilson Abrão
dc.creatorCamargo, Luiz Antonio de Arruda
dc.creatorRenzi, Antonio
dc.creatorLuca Junior, Laurival Antonio de
dc.creatorMenani, José Vanderlei
dc.date2014-05-27T11:17:28Z
dc.date2016-10-25T21:21:14Z
dc.date2014-05-27T11:17:28Z
dc.date2016-10-25T21:21:14Z
dc.date1992-08-31
dc.date.accessioned2017-04-06T09:22:15Z
dc.date.available2017-04-06T09:22:15Z
dc.identifierNeuroscience Letters, v. 143, n. 1-2, p. 255-258, 1992.
dc.identifier0304-3940
dc.identifierhttp://hdl.handle.net/11449/130473
dc.identifierhttp://acervodigital.unesp.br/handle/11449/130473
dc.identifier10.1016/0304-3940(92)90277-E
dc.identifierWOS:A1992JP03000059
dc.identifier2-s2.0-0026714506
dc.identifierhttp://dx.doi.org/10.1016/0304-3940(92)90277-E
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/941016
dc.descriptionThe present study was performed to investigate the effect of treatment with furosemide on the pressor response induced by intracerebroventricular (i.c.v.) injections of cholinergic (carbachol) and adrenergic (norepinephrine) agonists, angiotensin II (ANGII) and hypertonic saline (HS, 2 M NaCl). The changes induced by furosemide treatment on the pressor response to intravenous (i.v.) norepinephrine, ANGII and arginine vasopressin (AVP) were also studied. Rats with a stainless-steel cannula implanted into the lateral ventricle (LV) were used. Two injections of furosemide (30 mg/kg b.wt. each) were performed 12 and 1 h before the experiments. Treatment with furosemide reduced the pressor response induced by carbachol, norepinephrine and ANGII i.c.v., but no change was observed in the pressor response to i.c.v. 2 M NaCl. The pressor response to i.v. ANGII and norepinephrine, but not AVP, was also reduced after treatment with furosemide. These results show that the treatment with furosemide impairs the pressor responses induced by central or peripheral administration of adrenergic agonist or ANGII, as well as those induced by central cholinergic activation. The results suggest that the treatment with furosemide impairs central and peripheral pressor responses mediated by sympathetic activation and ANGII, but not those produced by AVP. © 1992.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdrenergic drug
dc.subjectAngiotensin II
dc.subjectDiuretic
dc.subjectFurosemide
dc.subjectHypertension
dc.subjectVasopressin
dc.subjectAngiotensin
dc.subjectArgipressin
dc.subjectCarbachol
dc.subjectFurosemide
dc.subjectNoradrenalin
dc.subjectAnimal experiment
dc.subjectBlood pressure
dc.subjectCatecholaminergic system
dc.subjectCholinergic system
dc.subjectControlled study
dc.subjectDrug sensitivity
dc.subjectIntracerebroventricular drug administration
dc.subjectIntramuscular drug administration
dc.subjectIntravenous drug administration
dc.subjectMale
dc.subjectNonhuman
dc.subjectPriority journal
dc.subjectRat
dc.subjectAnimal
dc.subjectArgipressin
dc.subjectBlood Pressure
dc.subjectCarbachol
dc.subjectInjections, Intravenous
dc.subjectInjections, Intraventricular
dc.subjectMale
dc.subjectNorepinephrine
dc.subjectRats
dc.subjectSaline Solution, Hypertonic
dc.subjectSupport, Non-U.S. Gov't
dc.subjectVasoconstriction
dc.titleEffect of furosemide treatment on the central and peripheral pressor responses to cholinergic and adrenergic agonists, angiotensin II, hypertonic solution and vasopressin
dc.typeOtro


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