Synergist interaction between angiotensin II and DOCA on sodium and water balance in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCamargo, Luiz Antonio de Arruda
dc.creatorSaad, Wilson Abrão
dc.creatorLuca Junior, Laurival Antonio de
dc.creatorRenzi, Antonio
dc.creatorSilveira, José Eduardo Nogueira
dc.creatorMenani, José Vanderlei
dc.date2014-05-27T11:17:56Z
dc.date2016-10-25T21:21:11Z
dc.date2014-05-27T11:17:56Z
dc.date2016-10-25T21:21:11Z
dc.date1994-03-01
dc.date.accessioned2017-04-06T09:22:03Z
dc.date.available2017-04-06T09:22:03Z
dc.identifierPhysiology and Behavior, v. 55, n. 3, p. 423-427, 1994.
dc.identifier0031-9384
dc.identifierhttp://hdl.handle.net/11449/130451
dc.identifierhttp://acervodigital.unesp.br/handle/11449/130451
dc.identifierhttp://dx.doi.org/10.1016/0031-9384(94)90095-7
dc.identifierWOS:A1994MY68400005
dc.identifier2-s2.0-0028280810
dc.identifierhttp://www.sciencedirect.com/science/article/pii/0031938494900957
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/940994
dc.descriptionBlockade of central angiotensin receptors with the specific antagonist [Leu8]-ANG II abolished water ingestion and water and sodium excretion induced by infusion of angiotensin II (ANGII) into the lateral ventricle (LV) of rats. The antagonist reduced but did not suppress the salt appetite induced by ANGII infusion. Subcutaneous injection of deoxycorticosterone acetate (DOCA) caused increases in water and 3% NaCl ingestion and decreases in sodium excretion. When central ANGII infusion was combined with peripheral DOCA, the water intake was similar to that induced by ANGII alone and the ingestion of 3% NaCl was increased, whereas sodium excretion was inhibited. When ANGII was infused alone, a detailed temporal analysis of fluid and sodium balance showed a negative balance similar those saline controls that persisted throughout the experiment. Combined administration of ANGII and DOCA induce significant changes in water and sodium balance. Sodium and water maintained a positive balance through out the 8-h experiment. The data support an interaction of central ANGII and DOCA on sodium intake and water and sodium balance. © 1994.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationPhysiology and Behavior
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAngiotensin II
dc.subjectDOCA
dc.subjectSalt ingestion
dc.subjectSodium excretion
dc.subjectUrine excretion
dc.subjectWater ingestion
dc.subjectAngiotensin
dc.subjectAngiotensin 2 receptor antagonist
dc.subjectDeoxycorticosterone acetate
dc.subjectAnimal experiment
dc.subjectControlled study
dc.subjectFluid balance
dc.subjectFluid intake
dc.subjectIntracerebroventricular drug administration
dc.subjectMale
dc.subjectNatriuresis
dc.subjectNonhuman
dc.subjectPriority journal
dc.subjectRat
dc.subjectSalt intake
dc.subjectSubcutaneous drug administration
dc.subjectAnimal
dc.subjectDesoxycorticosterone
dc.subjectHomeostasis
dc.subjectMale
dc.subjectNatriuresis
dc.subjectRats
dc.subjectSupport, Non-U.S. Gov't
dc.subjectWater-Electrolyte Balance
dc.titleSynergist interaction between angiotensin II and DOCA on sodium and water balance in rats
dc.typeOtro


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