Acute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTraesel, Giseli Karenina
dc.creatorSouza, Juliane Coelho de
dc.creatorBarros, Aline Lima de
dc.creatorSouza, Marcos Alexandre
dc.creatorSchmitz, Wanderley Onofre
dc.creatorMuzzi, Rozanna Marques
dc.creatorOesterreich, Silvia Aparecida
dc.creatorArena, Arielle Cristina
dc.date2015-11-03T15:28:18Z
dc.date2016-10-25T21:16:55Z
dc.date2015-11-03T15:28:18Z
dc.date2016-10-25T21:16:55Z
dc.date2014-12-01
dc.date.accessioned2017-04-06T09:16:50Z
dc.date.available2017-04-06T09:16:50Z
dc.identifierFood And Chemical Toxicology. Oxford: Pergamon-elsevier Science Ltd, v. 74, p. 320-325, 2014.
dc.identifier0278-6915
dc.identifierhttp://hdl.handle.net/11449/129973
dc.identifierhttp://acervodigital.unesp.br/handle/11449/129973
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2014.10.026
dc.identifierWOS:000347274600042
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0278691514004554
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/940525
dc.descriptionAcrocomia aculeata, popularly known as "bocaitiva", is a species used for nutritional purposes and for the treatment of various diseases, as it has, among other things, high levels of antioxidant compounds. This study aimed to assess the toxicological profile of A. aculeata, through acute and subacute toxicity tests. Male and female rats (Wistar) received by gavage 2000 mg/kg of oil extracted from the pulp of A. aculeata (OPAC) for the acute toxicity test and 125, 250, 500 or 1000 mg/kg of OPAC for subacute toxicity test. In the acute toxicity study no mortality or behavioral changes were observed in rats treated with 2000 mg/kg, indicating that the LD50 is higher than this dose. In the subacute toxicity test, the tested doses produced no significant changes in hematological, biochemical or histopathological parameters in the animals exposed. These results demonstrate the absence of acute and subacute toxicity after oral exposure to A. aculeata oil in rats. However, further studies in animals and in humans are needed in order to have sufficient safety evidence for its use in humans. (C) 2014 Elsevier Ltd. All rights reserved.
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationFood And Chemical Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcrocomia aculeata
dc.subjectAcute toxicity
dc.subjectSubacute toxicity
dc.subjectSafety
dc.subjectRats
dc.titleAcute and subacute (28 days) oral toxicity assessment of the oil extracted from Acrocomia aculeata pulp in rats
dc.typeOtro


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