dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.creator | Mendonca dos Santos, Ana Claudia | |
dc.creator | Santos Akkari, Alessandra Cristina | |
dc.creator | Silva Ferreira, Iasmin Rosanne | |
dc.creator | Maruyama, Cintia Rodrigues | |
dc.creator | Pascoli, Monica | |
dc.creator | Guilherme, Viviane Aparecida | |
dc.creator | Paula, Eneida de | |
dc.creator | Fraceto, Leonardo Fernandes | |
dc.creator | Lima, Renata de | |
dc.creator | Melo, Patricia da Silva | |
dc.creator | Araujo, Daniele Ribeiro de | |
dc.date | 2015-10-21T21:19:54Z | |
dc.date | 2016-10-25T21:09:25Z | |
dc.date | 2015-10-21T21:19:54Z | |
dc.date | 2016-10-25T21:09:25Z | |
dc.date | 2015-01-01 | |
dc.date.accessioned | 2017-04-06T09:10:44Z | |
dc.date.available | 2017-04-06T09:10:44Z | |
dc.identifier | International Journal Of Nanomedicine, v. 10, p. 2391-2401, 2015. | |
dc.identifier | 1178-2013 | |
dc.identifier | http://hdl.handle.net/11449/129545 | |
dc.identifier | http://acervodigital.unesp.br/handle/11449/129545 | |
dc.identifier | http://dx.doi.org/10.2147/IJN.S72337 | |
dc.identifier | WOS:000351616800001 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/940100 | |
dc.description | In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, and in vivo pharmacological performance of PL 407 and PL 407-PL 188 hydrogels containing tramadol (TR) to analyze its potential treatment of acute pain. Drug-micelle interaction studies showed the formation of PL 407-PL 188 binary systems and the drug partitioning into the micelles. Characterization of the sol-gel transition phase showed an increase on enthalpy variation values that were induced by the presence of TR hydrochloride within the PL 407 or PL 407-PL 188 systems. Hydrogel dissolution occurred rapidly, with approximately 30%-45% of the gel dissolved, reaching similar to 80%-90% up to 24 hours. For in vitro release assays, formulations followed the diffusion Higuchi model and lower K-rel values were observed for PL 407 (20%, K-rel = 112.9 +/- 10.6 mu g . h(-1/2)) and its binary systems PL 407-PL 188 (25%-5% and 25%-10%, K-rel = 80.8 +/- 6.1 and 103.4 +/- 8.3 mu g.h(-1/2), respectively) in relation to TR solution (K-rel = 417.9 +/- 47.5 mu g.h(-1/2), P<0.001). In addition, the reduced cytotoxicity (V79 fibroblasts and hepatocytes) and genotoxicity (V79 fibroblasts), as well as the prolonged analgesic effects (>72 hours) pointed to PL-based hydrogels as a potential treatment, by subcutaneous injection, for acute pain. | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | |
dc.language | eng | |
dc.publisher | Dove Medical Press Ltd | |
dc.relation | International Journal Of Nanomedicine | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | micelle | |
dc.subject | cytotoxicity | |
dc.subject | genotoxicity | |
dc.subject | analgesia | |
dc.title | Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation | |
dc.type | Otro | |