The mediating role of physical inactivity on the relationship between inflammation and artery thickness in prepubertal adolescents

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCayres, Suziane Ungari
dc.creatorLira, Fabio Santos de
dc.creatorMachado-Rodrigues, Aristides M.
dc.creatorFreitas Junior, Ismael Forte
dc.creatorBarbosa, Mauricio Fregonesi
dc.creatorFernandes, Romulo Araujo
dc.date2015-10-21T20:49:14Z
dc.date2016-10-25T21:08:53Z
dc.date2015-10-21T20:49:14Z
dc.date2016-10-25T21:08:53Z
dc.date2015-04-01
dc.date.accessioned2017-04-06T09:08:47Z
dc.date.available2017-04-06T09:08:47Z
dc.identifierJournal Of Pediatrics. New York: Mosby-elsevier, v. 166, n. 4, p. 924-929, 2015.
dc.identifier0022-3476
dc.identifierhttp://hdl.handle.net/11449/129313
dc.identifierhttp://acervodigital.unesp.br/handle/11449/129313
dc.identifierhttp://dx.doi.org/10.1016/j.jpeds.2014.12.057
dc.identifierWOS:000353385700029
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0022347614012268
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/939868
dc.descriptionObjective: To analyze the relationship between inflammatory markers and the lipid profile, blood flow, and artery structure in prepubertal adolescents stratified according to sports practice.Study design The sample was composed of 120 adolescents (57 boys and 63 girls) with a mean age of 11.7 +/- 0.7 years (ranging from 11 to 13 years). Intima-media thickness (IMT) and blood flow were measured with ultrasonography. The lipid profile and high-sensitivity C-reactive protein were measured after the subjects had fasted for 12 hours overnight. Trunk fatness was measured by dual-energy x-ray absorptiometry. Organized sports participation was analyzed as a categorical variable. Biological maturation was determined via the age at peak height velocity. Results: In the adjusted model, high-sensitivity C-reactive protein was significantly related to high-density lipoprotein-cholesterol (beta = -5.797 [-11.500 to -0.093]), femoral IMT (beta = 0.062 [0.008-0.116]), and the sum of femoral and carotid IMT (beta = 1.107 [0.223-1.919]), but only in the group without sports participation. Slopes of the crude linear regression were greater in the group without sports participation for femoral IMT (t = 2.621; P = .009) and the sum of femoral and carotid IMT (t = 2.876; P = .004) when compared with the group with sports participation. Conclusion: Independent of body fatness and biological maturation, inflammatory status was related to artery IMT and dyslipidemia in prepubertal adolescents, modulated by sport participation.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherElsevier B.V.
dc.relationJournal Of Pediatrics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.titleThe mediating role of physical inactivity on the relationship between inflammation and artery thickness in prepubertal adolescents
dc.typeOtro


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