dc.contributor | Universidade Estadual Paulista (UNESP) | |
dc.creator | Lisboa, Mario R. P. | |
dc.creator | Gondim, Delane V. | |
dc.creator | Ervolino, Edilson | |
dc.creator | Vale, Mariana L. | |
dc.creator | Frota, Nicolly P. R. | |
dc.creator | Nunes, Nara L. T. | |
dc.creator | Mariguela, Viviane C. | |
dc.creator | Taba, Mario | |
dc.creator | Messora, Michel R. | |
dc.creator | Furlaneto, Flavia A. C. | |
dc.date | 2015-10-21T13:10:10Z | |
dc.date | 2016-10-25T20:59:42Z | |
dc.date | 2015-10-21T13:10:10Z | |
dc.date | 2016-10-25T20:59:42Z | |
dc.date | 2015-06-01 | |
dc.date.accessioned | 2017-04-06T08:58:36Z | |
dc.date.available | 2017-04-06T08:58:36Z | |
dc.identifier | Journal Of Periodontology. Chicago: Amer Acad Periodontology, v. 86, n. 6, p. 801-811, 2015. | |
dc.identifier | 0022-3492 | |
dc.identifier | http://hdl.handle.net/11449/128472 | |
dc.identifier | http://acervodigital.unesp.br/handle/11449/128472 | |
dc.identifier | http://dx.doi.org/10.1902/jop.2015.140630 | |
dc.identifier | WOS:000355265900009 | |
dc.identifier | http://www.joponline.org/doi/10.1902/jop.2015.140630 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/939028 | |
dc.description | Background: Acupuncture has shown the capability of modulating the immuno-inflammatory response of the host. This study aims to evaluate the effects of electroacupuncture (EA) on ligature-induced periodontitis in rats. Methods: Thirty-two animals were divided into four groups: 1) control; 2) experimental periodontitis (EP); 3) sham-treated (EP/EA-sham); and 4) treated with EA (EP/EA). For the EP groups, a ligature was placed around the right mandibular first molars at day 1. Sessions of EA or EA-sham were assigned every other day. For EA treatment, large intestine meridian points LI4 and LI11 and stomach meridian points ST36 and ST44 were used. EA-sham was performed in off-meridian points. Animals were euthanized at day 11. Histomorphometric and microtomographic analyses were performed. Immunolabeling patterns for the receptor activator of nuclear factor kappa B ligand (RANKL), osteoprotegerin (OPG), and tartrate-resistant acid phosphatase (TRAP) were assessed. Expressions of interleukin (IL)-1 beta, matrix metalloproteinase (MMP)-8, IL-6, and cyclooxygenase (COX)-2 messenger RNAs (mRNAs) were evaluated by quantitative reverse transcription-polymerase chain reaction. Data were analyzed statistically (P < 0.05, analysis of variance). Results: Histomorphometric and microtomographic analyses demonstrated that group EP/EA presented reduced alveolar bone loss when compared to group EP (P < 0.05). Reduced RANKL immunolabeling and fewer TRAP-positive multinucleated cells were observed in the EA-treated group in relation to group EP. No differences were observed in OPG expression among groups. EA treatment decreased the genic expression of IL-1 beta and MMP-8 (P < 0.05), increased the mRNA expression of IL-6 (P < 0.05), and did not modify the genic expression of COX-2 in animals with EP (P > 0.05). Conclusion: It can be concluded that EA reduced periodontal tissue breakdown and the expression of some proinflammatory mediators and a proresorptive factor in EP in rats. | |
dc.language | eng | |
dc.publisher | Amer Acad Periodontology | |
dc.relation | Journal Of Periodontology | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Bone resorption | |
dc.subject | Electroacupuncture | |
dc.subject | Inflammation mediators | |
dc.subject | Periodontitis | |
dc.title | Effects of electroacupuncture on experimental periodontitis in rats | |
dc.type | Otro | |