Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCaldeira Xavier-Júnior, Jose Candido
dc.creatorMunhoz, Tania
dc.creatorSouza, Vinicius
dc.creatorPires de Campos, Eloisa Bueno
dc.creatorStolf, Hamilton Ometto
dc.creatorAlencar Marques, Mariangela Esther
dc.date2015-10-21T13:08:58Z
dc.date2016-10-25T20:59:19Z
dc.date2015-10-21T13:08:58Z
dc.date2016-10-25T20:59:19Z
dc.date2015-06-20
dc.date.accessioned2017-04-06T08:57:18Z
dc.date.available2017-04-06T08:57:18Z
dc.identifierDiagnostic Pathology. London: Biomed Central Ltd, v. 10, p. 1-4, 2015.
dc.identifier1746-1596
dc.identifierhttp://hdl.handle.net/11449/128321
dc.identifierhttp://acervodigital.unesp.br/handle/11449/128321
dc.identifierhttp://dx.doi.org/10.1186/s13000-015-0307-z
dc.identifierWOS:000356654300001
dc.identifierWOS000356654300001.pdf
dc.identifierhttp://www.diagnosticpathology.org/content/10/1/73
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/938877
dc.descriptionBackground: Acral lentiginous melanoma is a melanoma with poor prognosis which is frequently diagnosed at an advanced stage. Since the thickness of tumour is one of the main prognostic factors, this case can exemplify how important complete histological analyses looking for focal invasiveness can be.Case report: A 77 year-old woman with a black spot with slow progressive growth on the left plantar region. She sought medical attention due to the expansion onto the dorsal surface of toes. The lesion had irregular borders and had spread to half the plantar surface. Histopathology confirmed the clinical suspicion of acral lentiginous melanoma Clark level IV and 2.6 mm Breslow thickness. The surgical specimen was entirely processed for histological evaluation, requiring 53 slides. Tumor dermal invasion was detected in only three out of 53 glass slides as the invasiveness was not identified by clinical, dermatoscopy or macroscopy exams.Conclusion: Sectioning through the entire lesion is considered very important to determinate the appropriate stage of the disease and the correct treatment and patient follow-up.
dc.languageeng
dc.publisherBiomed Central Ltd
dc.relationDiagnostic Pathology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMelanoma
dc.subjectDermatopathology
dc.subjectCancer
dc.subjectAcral Lentiginous Melanoma
dc.titleFocal invasiveness in complete histological analyses of a large acral lentiginous melanoma
dc.typeOtro


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