Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorLuvizotto, R. A. M.
dc.creatorNascimento, A. F.
dc.creatorMiranda, N. C. M.
dc.creatorWang, X-D
dc.creatorFerreira, A. L. A.
dc.date2015-10-21T13:08:53Z
dc.date2016-10-25T20:59:18Z
dc.date2015-10-21T13:08:53Z
dc.date2016-10-25T20:59:18Z
dc.date2015-06-01
dc.date.accessioned2017-04-06T08:57:12Z
dc.date.available2017-04-06T08:57:12Z
dc.identifierHuman &experimental Toxicology. London: Sage Publications Ltd, v. 34, n. 6, p. 612-619, 2015.
dc.identifier0960-3271
dc.identifierhttp://hdl.handle.net/11449/128309
dc.identifierhttp://acervodigital.unesp.br/handle/11449/128309
dc.identifierhttp://dx.doi.org/10.1177/0960327114551395
dc.identifierWOS:000355334400005
dc.identifierhttp://het.sagepub.com/content/34/6/612
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/938865
dc.descriptionAim: To investigate whether lycopene can modulate adiponectin levels and SIRT1 and FoxO1 gene expression in the adipose tissue of diet-induced obese rats.Methods: Male Wistar rats were first fed with hypercaloric diet (HD, n = 12) for 6 weeks, and afterward, these rats were randomly assigned to receive HD (n = 6) or HD with lycopene-rich tomato oleoresin (equivalent to lycopene 10 mg/kg body weight (BW)/day, HD + L, n = 6) by gavage for additional 6 weeks. Plasma lycopene and adiponectin levels were analyzed by high-performance liquid chromatography and immunoassay, respectively. The messenger RNA (mRNA) expressions of adiponectin, Sirtuin 1 (SIRT1), Forkhead box O 1 (FoxO1), fatty acid translocase/cluster of differentiation 36 (FAT/CD36), and PPAR in adipose tissues were determined by quantitative polymerase chain reaction.Results: Lycopene was detected in the plasma of rats in HD + L group but not in the HD group. Although both BW and adiposity were not different between the two groups, there was a significant increase in both plasma concentration and mRNA expression of adiponectin in the adipose tissue of the HD + L group. In addition, the lycopene supplementation upregulated mRNA expressions of SIRT1, FoxO1, and FAT/CD36 but downregulated PPAR in adipose tissue of obese rats.Conclusion: These data suggest that lycopene, in the concentration used, is not toxic and also its health benefits in adipose tissue may play a role against obesity-related complications.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherSage Publications Ltd
dc.relationHuman &experimental Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdiponectin
dc.subjectFoxO1
dc.subjectLycopene
dc.subjectobesity
dc.subjectSIRT1
dc.titleLycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats
dc.typeOtro


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