Hemoglobin I-Philadelphia [alpha 16 (A14) LYS→GLU] heterozygote among blood donors from Brazil

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTorres, F. R.
dc.creatorOndei, L. S.
dc.creatorZamaro, P. J. A.
dc.creatorSilva, R. U.
dc.creatorCavasini, C. E.
dc.creatorRossit, A. R. B.
dc.creatorMachado, R. L. D.
dc.creatorBonini-Domingos, C. R.
dc.date2015-09-10T12:33:20Z
dc.date2016-10-25T20:57:36Z
dc.date2015-09-10T12:33:20Z
dc.date2016-10-25T20:57:36Z
dc.date2006-01-01
dc.date.accessioned2017-04-06T08:50:49Z
dc.date.available2017-04-06T08:50:49Z
dc.identifierGenetics and Molecular Research, v. 5, n. 4, p. 713-716, 2006.
dc.identifier1676-5680
dc.identifierhttp://hdl.handle.net/11449/38238
dc.identifierhttp://acervodigital.unesp.br/handle/11449/38238
dc.identifierWOS:000203012000013
dc.identifierWOS000203012000013.pdf
dc.identifier2-s2.0-33845424973
dc.identifierhttp://www.geneticsmr.com/articles/307
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/938088
dc.descriptionWe describe a heterozygous case of Hb I-Philadelphia [alpha 16 (A14) LYS-->GLU] in a blood donor from the Acre State Blood Bank, in the Brazilian Amazon region. We confirmed the mutation by electrophoretic and chromatographic methods and by DNA sequencing. A literature search showed that this is the first description of this alpha globin mutant in a Brazilian Caucasian group. We also emphasize the importance of the hemoglobin study in blood donors for the purpose of the genetic counseling and quality assurance of the blood to be transfused. Screening tests for hemoglobin mutants are also important for gathering anthropological information about the Brazilian population.
dc.languageeng
dc.publisherFunpec-editora
dc.relationGenetics and Molecular Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHb I-Philadelphia
dc.subjectrare hemoglobin
dc.subjectHPLC
dc.subjectblood donors
dc.titleHemoglobin I-Philadelphia [alpha 16 (A14) LYS→GLU] heterozygote among blood donors from Brazil
dc.typeOtro


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