Luteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorNogueira, Marcelo Fábio Gouveia
dc.creatorFernandes, Paulo
dc.creatorEreno, Ronaldo Luiz
dc.creatorSimões, Renato Arantes Lima
dc.creatorBuratini Júnior, José
dc.creatorBarros, Ciro Moraes
dc.date2015-08-21T17:52:58Z
dc.date2016-10-25T20:55:47Z
dc.date2015-08-21T17:52:58Z
dc.date2016-10-25T20:55:47Z
dc.date2010
dc.date.accessioned2017-04-06T08:44:12Z
dc.date.available2017-04-06T08:44:12Z
dc.identifierAnimal Reproduction, v. 7, n. 2, p. 51-64, 2010.
dc.identifier1806-9614
dc.identifierhttp://hdl.handle.net/11449/126730
dc.identifierhttp://acervodigital.unesp.br/handle/11449/126730
dc.identifierISSN1806-9614-2010-07-02-51-64.pdf
dc.identifier3734933152414412
dc.identifier7795883009987806
dc.identifierhttp://www.cbra.org.br/portal/publicacoes/ar/2010/araj2010.html
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/937306
dc.descriptionAcquisition of the luteinizing hormone receptor (LHR) on granulosa cells of the dominant follicle is essential to physiological LH-mediated effects on the final stages of follicular growth, final maturation of the oocyte, ovulation and luteinization of the follicular wall. Therefore, LHR plays a key role in the final maturation of the dominant follicle from follicular dominance to ovulation. In this review, the basic molecular aspects of LHR (gene structure, alternative splicing and ligand mediated activation) and the physiological regulatory aspects (changes in LHR expression during antral follicle growth and a post-transcriptional model for downregulation of LHR transcripts) are addressed. Despite the accumulation of considerable amounts of information about LHR, a comprehensive and broad model for the role of LHR in bovine antral follicle growth is missing. Questions such as the function for alternative LHR transcripts, their transcriptional and translational regulation, and how the transcripts go to the cell surface and interact with ligands remain to be elucidated in bovine and other species.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.relationAnimal Reproduction
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBos indicus
dc.subjectBos taurus
dc.subjectCattle
dc.subjectFolliculogenesis
dc.subjectGranulosa cells
dc.subjectLHR
dc.subjectLuteinizing hormone receptor
dc.subjectOvulation
dc.titleLuteinizing Hormone Receptor (LHR): basic concepts in cattle and other mammals. a review
dc.typeOtro


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