Activation of μ opioid receptors in the LPBN facilitates sodium intake in rats

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPavan, Carolina G.
dc.creatorRoncari, Camila F.
dc.creatorBarbosa, Silas P.
dc.creatorPaula, Patricia Maria de
dc.creatorColombari, Débora S. A.
dc.creatorLuca Júnior, Laurival A. de
dc.creatorColombari, Eduardo
dc.creatorMenani, José V.
dc.date2015-08-06T16:12:56Z
dc.date2016-10-25T20:53:32Z
dc.date2015-08-06T16:12:56Z
dc.date2016-10-25T20:53:32Z
dc.date2015
dc.date.accessioned2017-04-06T08:35:51Z
dc.date.available2017-04-06T08:35:51Z
dc.identifierBehavioural Brain Research, v. 288, p. 20-25, 2015.
dc.identifier0166-4328
dc.identifierhttp://hdl.handle.net/11449/125723
dc.identifierhttp://acervodigital.unesp.br/handle/11449/125723
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2015.03.047
dc.identifier0201361251312074
dc.identifier4544450092427426
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0166432815002120
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/936316
dc.descriptionImportant inhibitory mechanisms for the control of water and sodium intake are present in the lateral parabrachial nucleus (LPBN). Opioid receptors are expressed by LPBN neurons and injections of endorphin (nonspecific opioid receptor agonist) in this area induce 0.3 M NaCl and water intake in satiated rats. In the present study, we investigated the effects of the injections of endomorphin-1 (opioid receptor agonist) alone or combined with the blockade of , or opioid receptors into the LPBN on 0.3 M NaCl and water intake induced by subcutaneous injections of the diuretic furosemide (FURO) combined with low dose of the angiotensin converting enzyme inhibitor captopril (CAP). Male Holtzman rats with stainless steel cannulas implanted bilaterally in the LPBN were used. Bilateral injections of endomorphin-1 (0.1, 0.25, 0.5, 1.0, 2.0 and 4.0 nmol/0.2 l) into the LPBN increased 0.3 M NaCl and water intake induced by FURO + CAP. The previous blockade of opioid receptor with CTAP (1.0 nmol/0.2 l) into the LPBN reduced the effect of endomorphin-1 on FURO + CAP-induced 0.3 M NaCl. GNTI ( opioid receptor antagonist; 2.0 nmol/0.2 l) and naltrindole ( opioid receptor antagonist; 2.0 nmol/0.2 l) injected into the LPBN did not change the effects of endomorphin-1 on FURO + CAP-induced 0.3 M NaCl. The results suggest that opioid receptors in the LPBN are involved in the control of sodium intake.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.relationBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSodium appetite
dc.subjectEndomorphin
dc.subjectμ Opioid receptor
dc.subjectParabrachial nucleus
dc.titleActivation of μ opioid receptors in the LPBN facilitates sodium intake in rats
dc.typeOtro


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