dc.contributor | maciejbanach@aol.co.uk | |
dc.creator | Dinca, Madalina | |
dc.creator | Serban, Maria-Corina | |
dc.creator | Sahebkar, Amirhossein | |
dc.creator | Mikhailidis, Dimitri P | |
dc.creator | Toth, Peter P | |
dc.creator | Martin, Seth S | |
dc.creator | Blaha, Michael J | |
dc.creator | Blüher, Matthias | |
dc.creator | Gurban, Camelia | |
dc.creator | Penson, Peter | |
dc.creator | Michos, Erin D | |
dc.creator | Hernandez, Adrian V. | |
dc.creator | Jones, Steven R | |
dc.creator | Banach, Maciej | |
dc.date.accessioned | 2016-04-19T13:36:10Z | |
dc.date.accessioned | 2024-05-06T19:27:18Z | |
dc.date.available | 2016-04-19T13:36:10Z | |
dc.date.available | 2024-05-06T19:27:18Z | |
dc.date.created | 2016-04-19T13:36:10Z | |
dc.date.issued | 2016-03-30 | |
dc.identifier | Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. 2016, 107:360-371 Pharmacol. Res. | |
dc.identifier | 1096-1186 | |
dc.identifier | 27038530 | |
dc.identifier | 10.1016/j.phrs.2016.03.035 | |
dc.identifier | http://hdl.handle.net/10757/605887 | |
dc.identifier | Pharmacological research | |
dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/9290198 | |
dc.description.abstract | We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta-analysis of data from 7 studies did not find a significant change in plasma adiponectin concentrations following vitamin D supplementation (mean difference [MD]: 4.45%, 95%CI: -3.04, 11.93, p=0.244; Q=2.18, I(2)=0%). In meta-regression, changes in plasma adiponectin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: 0.25; 95%CI: -0.69, 1.19; p=0.603) and changes in serum 25-hydroxy vitamin D [25(OH)D] levels (slope: -0.02; 95%CI: -0.15, 0.12; p=0.780). Meta-analysis of data from 6 studies did not find a significant change in plasma leptin concentrations following vitamin D supplementation (MD: -4.51%, 95%CI: -25.13, 16.11, p=0.668; Q=6.41, I(2)=21.97%). Sensitivity analysis showed that this effect size is sensitive to one of the studies; removing it resulted in a significant reduction in plasma leptin levels (MD: -12.81%, 95%CI: -24.33, -1.30, p=0.029). In meta-regression, changes in plasma leptin concentrations following vitamin D supplementation were found to be independent of treatment duration (slope: -1.93; 95%CI: -4.08, 0.23; p=0.080). However, changes in serum 25(OH)D were found to be significantly associated with changes in plasma leptin levels following vitamin D supplementation (slope: 1.05; 95%CI: 0.08, 2.02; p=0.033). In conclusion, current data did not indicate a significant effect of vitamin D supplementation on adiponectin and leptin levels. | |
dc.language | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation | https://www.researchgate.net/profile/Maciej_Banach/publication/298064313_Does_vitamin_D_supplementation_alter_plasma_adipokines_concentrations_A_systematic_review_and_meta-analysis_of_randomized_controlled_trials/links/56fefd7008aee995dde73c14.pdf | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.source | Universidad Peruana de Ciencias Aplicadas (UPC) | |
dc.source | Repositorio Académico - UPC | |
dc.subject | Vitamin D | |
dc.subject | Adiponectin | |
dc.subject | Leptin | |
dc.subject | Meta-analysis | |
dc.subject | Systematic review | |
dc.title | Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. | |
dc.type | info:eu-repo/semantics/article | |