Treatment of osteochondral injuries with platelet gel

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorDanieli, Marcus Vinicius
dc.creatorPereira, Hamilton da Rosa
dc.creatorSa Carneiro, Carlos Augusto de
dc.creatorFelisbino, Sergio Luiz
dc.creatorDeffune, Elenice
dc.date2015-03-18T15:56:36Z
dc.date2016-10-25T20:35:50Z
dc.date2015-03-18T15:56:36Z
dc.date2016-10-25T20:35:50Z
dc.date2014-01-01
dc.date.accessioned2017-04-06T07:19:48Z
dc.date.available2017-04-06T07:19:48Z
dc.identifierClinics. Sao Paulo: Hospital Clinicas, Univ Sao Paulo, v. 69, n. 10, p. 694-698, 2014.
dc.identifier1807-5932
dc.identifierhttp://hdl.handle.net/11449/117637
dc.identifierhttp://acervodigital.unesp.br/handle/11449/117637
dc.identifier10.6061/clinics/2014(10)08
dc.identifierWOS:000346073000008
dc.identifierWOS000346073000008.pdf
dc.identifierhttp://dx.doi.org/10.6061/clinics/2014(10)08
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/928284
dc.descriptionOBJECTIVES: Treatments for injured articular cartilage have not advanced to the point that efficient regeneration is possible. However, there has been an increase in the use of platelet-rich plasma for the treatment of several orthopedic disorders, including chondral injuries. Our hypothesis is that the treatment of chondral injuries with platelet gel results in higher-quality repair tissue after 180 days compared with chondral injuries not treated with gel.METHODS: A controlled experimental laboratory study was performed on 30 male rabbits to evaluate osteochondral injury repair after treatment with or without platelet gel. Osteochondral injuries were surgically induced in both knees of each rabbit at the medial femoral condyle. The left knee injury was filled with the platelet gel, and the right knee was not treated. Microscopic analysis of both knee samples was performed after 180 days using a histological grading scale.RESULTS: The only histological evaluation criterion that was not significantly different between treatments was metachromasia. The group that was treated with platelet gel exhibited superior results in all other criteria (cell morphology, surface regularity, chondral thickness and repair tissue integration) and in the total score.CONCLUSION: The repair tissue was histologically superior after 180 days in the study group treated with platelet gel compared with the group of untreated injuries.
dc.languageeng
dc.publisherHospital Clinicas, Univ Sao Paulo
dc.relationClinics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPlatelet-Rich Plasma
dc.subjectArticular Cartilage
dc.subjectInjuries
dc.subjectRegenerative Medicine
dc.titleTreatment of osteochondral injuries with platelet gel
dc.typeOtro


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