Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorChapla, Vanessa Mara
dc.creatorZeraik, Maria Luiza
dc.creatorLeptokarydis, Ioanis Hcristos
dc.creatorSilva, Geraldo Humberto
dc.creatorBolzani, Vanderlan da Silva
dc.creatorYoung, Maria Claudia M.
dc.creatorPfenning, Ludwig Heinrich
dc.creatorAraújo, Angela Regina
dc.date2015-03-18T15:56:21Z
dc.date2016-10-25T20:35:33Z
dc.date2015-03-18T15:56:21Z
dc.date2016-10-25T20:35:33Z
dc.date2014-11-01
dc.date.accessioned2017-04-06T07:18:32Z
dc.date.available2017-04-06T07:18:32Z
dc.identifierMolecules. Basel: Mdpi Ag, v. 19, n. 11, p. 19243-19252, 2014.
dc.identifier1420-3049
dc.identifierhttp://hdl.handle.net/11449/117521
dc.identifierhttp://acervodigital.unesp.br/handle/11449/117521
dc.identifier10.3390/molecules191119243
dc.identifierWOS:000345564300128
dc.identifierWOS000345564300128.pdf
dc.identifier0000-0001-7616-9652
dc.identifierhttp://dx.doi.org/10.3390/molecules191119243
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/928168
dc.descriptionIn this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S*-Pro-S*-Tyr) (3), cyclo-(S*-Pro-S*-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl) acetic acid (6), 4-hydroxy-benzamide (7) and 2(2-hydroxyphenyl) acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 1-8 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageeng
dc.publisherMdpi Ag
dc.relationMolecules
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectColletotrichum gloeosporioides
dc.subjectendophytic fungus
dc.subjectantifungal activity
dc.titleAntifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca
dc.typeOtro


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