Determinants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorAraujo-Souza, Patricia S. de
dc.creatorRamanakumar, Agnihotram V.
dc.creatorCandeias, Joao M. G.
dc.creatorThomann, Patricia
dc.creatorTrevisan, Andrea
dc.creatorFranco, Eduardo L.
dc.creatorVilla, Luisa L.
dc.creatorLudwig-McGill Cohort Study
dc.date2015-03-18T15:55:51Z
dc.date2016-10-25T20:35:06Z
dc.date2015-03-18T15:55:51Z
dc.date2016-10-25T20:35:06Z
dc.date2014-11-18
dc.date.accessioned2017-04-06T07:16:26Z
dc.date.available2017-04-06T07:16:26Z
dc.identifierBmc Infectious Diseases. London: Biomed Central Ltd, v. 14, 9 p., 2014.
dc.identifier1471-2334
dc.identifierhttp://hdl.handle.net/11449/117332
dc.identifierhttp://acervodigital.unesp.br/handle/11449/117332
dc.identifier10.1186/s12879-014-0578-0
dc.identifierWOS:000345710200001
dc.identifierWOS000345710200001.pdf
dc.identifier0000-0003-1515-702X
dc.identifierhttp://dx.doi.org/10.1186/s12879-014-0578-0
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927979
dc.descriptionBackground: Immunity plays an important role in controlling human papillomavirus (HPV) infection and associated lesions. Unlike infections caused by other viruses, natural HPV infection does not always result in a protective antibody response. Therefore, HPV antibodies are also considered markers of cumulative exposure. The aim of this study was to identify determinants of HPV16 seroreactivity at enrollment among women from the Ludwig-McGill cohort, a natural history study of HPV infection and risk of cervical neoplasia.Methods: HPV16 serology was assessed by ELISA for L1 and L2 capsid antigens, while HPV typing and viral load measurements were performed by PCR-based methods. The associations were analyzed by unconditional logistic regression.Results: Of 2049 subjects, 425 (20.7%) were strongly seropositive for HPV16. In multivariate analysis, seroreactivity was positively correlated with age, lifetime number of sexual partners, frequency of sex, and HPV16 viral load, and negatively associated with duration of smoking.Conclusions: HPV16 seroreactivity is determined by factors that reflect viral exposure.
dc.languageeng
dc.publisherBiomed Central Ltd
dc.relationBmc Infectious Diseases
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSerology
dc.subjectHPV
dc.subjectNatural antibodies
dc.subjectHPV16 seropositivity
dc.titleDeterminants of baseline seroreactivity to human papillomavirus type 16 in the Ludwig-McGill cohort study
dc.typeOtro


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