Nanotechnological Strategies for Vaginal Administration of Drugs-A Review

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSilva, Patricia Bento da
dc.creatorSantos Ramos, Matheus Aparecido dos
dc.creatorBonifacio, Bruna Vidal
dc.creatorSilveira Negri, Kamila Maria
dc.creatorSato, Mariana Rillo
dc.creatorBauab, Taís Maria
dc.creatorChorilli, Marlus
dc.date2015-03-18T15:55:43Z
dc.date2016-10-25T20:34:59Z
dc.date2015-03-18T15:55:43Z
dc.date2016-10-25T20:34:59Z
dc.date2014-09-01
dc.date.accessioned2017-04-06T07:15:55Z
dc.date.available2017-04-06T07:15:55Z
dc.identifierJournal Of Biomedical Nanotechnology. Valencia: Amer Scientific Publishers, v. 10, n. 9, p. 2218-2243, 2014.
dc.identifier1550-7033
dc.identifierhttp://hdl.handle.net/11449/117285
dc.identifierhttp://acervodigital.unesp.br/handle/11449/117285
dc.identifier10.1166/jbn.2014.1890
dc.identifierWOS:000339430600023
dc.identifierhttp://dx.doi.org/10.1166/jbn.2014.1890
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/927932
dc.descriptionWomen frequently develop disorders related to the vaginal area, including problems with the immune system, hygiene, genetic aspects and sexually transmitted diseases. Compared with other mucosal application sites, the vagina represents local effect as well as systemic drug delivery and is able to avoid the first-pass effect due to its large surface area, high blood supply and permeability to many active ingredients. It has been widely proposed that the use of drugs to treat vaginal disorders be combined with nanotechnology because nanosystems often potentiate the action of most active constituents, reducing the required dosage and side effects and improving the resulting activity in comparison with conventional treatments. Following the trend of using drug delivery systems based on nanotechology, many studies have encouraged the scientific community to turn to the development of new strategies for the vaginal administration of drugs. This study proposes to review the most common nanotechnology-based drug delivery systems that have been used to improve the effectiveness of active compounds administrated to treat vaginal disorders.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherAmer Scientific Publishers
dc.relationJournal Of Biomedical Nanotechnology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNanotechnology
dc.subjectVaginal Disorders
dc.subjectDrug Delivery Systems
dc.subjectVaginal Administration
dc.subjectNanoformulations
dc.titleNanotechnological Strategies for Vaginal Administration of Drugs-A Review
dc.typeOtro


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